Head–Tail Asymmetry as the Determining Factor in the Formation of Polymer Cubosomes or Hexasomes in a Rod–Coil Amphiphilic Block Copolymer

Lyu, Xiaolin; Xiao, Anqi; Zhang, Wei; Hou, Pingping; Gu, Kehua; Tang, Zefang; Pan, Hongbing; Wu, Fan; Shen, Zhihao; Fan, Xinghe

doi:10.1002/anie.201804401

Cited by 55 publications

(60 citation statements)

References 27 publications

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“…Finally, vesicles are generally formed for 1/2 ≤ Cpp ≤ 1, which correspond to closed bilayer structures (sphere or ellipsoid) that have an internal cavity [16,17]. However, the amphiphile aggregates can be modulated to a wide range of other phases (such as rods, disks, ribbons, helix) or to ordered liquid crystalline morphologies by modifying certain control parameters, including the temperature, concentration, ionic strength and pH of the solution [23][24][25][26].…”

Section: Traditional Amphiphile Building Blocks: Micelles Vesicles mentioning

confidence: 99%

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

et al. 2020

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In this paper, we survey recent advances in the self-assembly processes of novel functional platforms for nanomaterials and biomaterials applications. We provide an organized overview, by analyzing the main factors that influence the formation of organic nanostructured systems, while putting into evidence the main challenges, limitations and emerging approaches in the various fields of nanotechology and biotechnology. We outline how the building blocks properties, the mutual and cooperative interactions, as well as the initial spatial configuration (and environment conditions) play a fundamental role in the construction of efficient nanostructured materials with desired functional properties. The insertion of functional endgroups (such as polymers, peptides or DNA) within the nanostructured units has enormously increased the complexity of morphologies and functions that can be designed in the fabrication of bio-inspired materials capable of mimicking biological activity. However, unwanted or uncontrollable effects originating from unexpected thermodynamic perturbations or complex cooperative interactions interfere at the molecular level with the designed assembly process. Correction and harmonization of unwanted processes is one of the major challenges of the next decades and requires a deeper knowledge and understanding of the key factors that drive the formation of nanomaterials. Self-assembly of nanomaterials still remains a central topic of current research located at the interface between material science and engineering, biotechnology and nanomedicine, and it will continue to stimulate the renewed interest of biologist, physicists and materials engineers by combining the principles of molecular self-assembly with the concept of supramolecular chemistry.

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Section: Traditional Amphiphile Building Blocks: Micelles Vesicles mentioning

confidence: 99%

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

et al. 2020

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“…Lin et al [128] employed a simple polystyrene-b-poly(ethylene oxide) (PS-PEO) diblock copolymer to obtain cubosomes with P and D surface mesophases, after which the selective solvent water was added to the dioxane/dimethylformamide solvent mixture to induce self-assembly. By using block copolymers comprised of different block types and structures, cubosomes with different structures and functions can be obtained [129][130][131][132][133][134][135][136][137].…”

Section: Artificial Self-assembly Of Amphiphilic Moleculesmentioning

confidence: 99%

Bicontinuous cubic phases in biological and artificial self-assembled systems

2020

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Nature has created innumerable life forms with miraculous hierarchical structures and morphologies that are optimized for different life events through evolution over billions of years. Bicontinuous cubic structures, which are often described by triply periodic minimal surfaces (TPMSs) and their constant mean curvature (CMC)/parallel surface companions, are of special interest to various research fields because of their complex form with unique physical functionalities. This has prompted the scientific community to fully understand the formation, structure, and properties of these materials. In this review, we summarize and discuss the formation mechanism and relationships of the relevant biological structures and the artificial self-assembly systems. These structures can be formed through biological processes with amazing regulation across a great length scales; nevertheless, artificial construction normally produces the structure corresponding to the molecular size and shape. Notably, the block copolymeric system is considered to be an applicable and attractive model system for the study of biological systems due to their versatile design and rich phase behavior. Some of the phenomena found in these two systems are compared and discussed, and this information may provide new ideas for a comprehensive understanding of the relationship between molecular shape and resulting interface curvature and the selfassembly process in living organisms. We argue that the copolymeric system may serve as a model to understand these biological systems and could encourage additional studies of artificial self-assembly and the creation of new functional materials.

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“…Kim et al investigated the formation of a series of ordered inverse morphologies using dendritic poly(ethylene oxide)-b-polystyrene BCPs in dilute solution, [9][10][11] while Mai and Fan groups reported the formation of ordered inverse morphologies with simpler linear diblock copolymers. [12,13] Over the past decade or so, polymerization-induced self-assembly (PISA) has been intensively investigated for efficient preparation of BCP nanoparticles, which enables reliable access to various particle morphologies at high concentrations (≥10% solid content). [14][15][16][17][18][19][20][21][22][23] In principle, the high efficiency (simultaneous polymerization and in situ BCP self-assembly) and high concentration (high probability of particle collision and thus effective fusion and reorganization) would provide a more viable means for the preparation of inverse morphologies.…”

Section: Doi: 101002/marc202000209mentioning

confidence: 99%

Polymerization‐Induced Self‐Assembly for the Synthesis of Poly(N,N‐dimethylacrylamide)‐b‐Poly(4‐tert‐butoxystyrene) Particles with Inverse Bicontinuous Phases

Luo

2020

Macromol. Rapid Commun.

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Polymerization‐induced self‐assembly (PISA) has been routinely used to produce block copolymer (BCP) particles with various morphologies, but inverse bicontinuous phases have remained scarce. Herein, PISA preparation of poly(N,N‐dimethylacrylamide‐b‐poly(4‐tert‐butoxystyrene) (PDMA‐b‐PtBOS) BCP particles with inverse bicontinuous phases in ethanol/water at 30% w/v solid content is reported. The effect of solvent composition and degree of polymerization of the core‐forming PtBOS block is investigated. tBOS monomer conversion is enhanced on increasing water content, and inverse bicontinuous phases are effectively produced using a short PDMA stabilizer block. Morphology studies by both transmission and scanning electron microscopies reveal that transitions from vesicles to compound vesicles to inverse bicontinuous phases are the key mechanistic steps toward the formation of (partially) ordered mesophases.

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Head–Tail Asymmetry as the Determining Factor in the Formation of Polymer Cubosomes or Hexasomes in a Rod–Coil Amphiphilic Block Copolymer

Cited by 55 publications

References 27 publications

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

Bicontinuous cubic phases in biological and artificial self-assembled systems

Polymerization‐Induced Self‐Assembly for the Synthesis of Poly(N,N‐dimethylacrylamide)‐b‐Poly(4‐tert‐butoxystyrene) Particles with Inverse Bicontinuous Phases

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