Headache and Biomarkers Predictive of Vascular Disease in a Representative Sample of US Children

Nelson, Karin B.; Richardson, Amanda; He, Jie; Lateef, Tarranum M.; Khoromi, Suzan; Merikangas, Kathleen R.

doi:10.1001/archpediatrics.2010.17

Cited by 42 publications

(41 citation statements)

References 44 publications

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“…Careful reading of title, abstract and full text (when available), allowed to exclude 118 articles, which did not reported original data about the epidemiological association between CRP and migraine, or did not use standardized criteria for diagnosis of migraine. Therefore, 17 clinical studies were finally included in this review, i.e., one retrospective, one interventional, 14 cross-sectional and one both interventional and cross-sectional (Table 1) [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Demographical information, along with the techniques used for measuring CRP [i.e., conventional or highsensitivity (HS)], were reported, whenever available.…”

Section: Overview On Epidemiological Datamentioning

confidence: 99%

“…Nelson et al carried out a very large cross-sectional study on 11,770 children or adolescents aged 4-19 years who were enrolled in the National Health and Nutrition Survey (NHANES) in 1999 through 2004, with an overall prevalence of frequent migraine of 19.5% (2295 cases) [19]. In this large population cohort, the concentration of CRP was found to be slightly but significantly higher in cases (1.9 ± 0.1 mg/L) than in controls (1.5 ± 0.1 mg/L; p < 0.01).…”

Section: Overview On Epidemiological Datamentioning

confidence: 99%

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C-reactive protein and migraine. Facts or speculations?

Lippi¹,

Mattiuzzi²,

Cervellin

2014

Clinical Chemistry and Laboratory Medicine

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Migraine is a highly prevalent and frequently disabling disorder. Since the pathogenesis of this condition has a strong inflammatory component and migraine is significantly associated with cardiovascular disease, we assess whether C-reactive protein (CRP) may be epidemiologically or casually linked with migraine. An electronic search on Medline, Scopus and Web of Science produced 17 studies reporting original data about the epidemiological association between CRP and migraine (1 retrospective, 1 interventional, 14 cross-sectional and 1 both interventional and cross-sectional). When all studies reporting sufficient data about CRP values were pooled (n = 12; 6980 cases and 38,975 controls), the concentration of CRP was found to be significantly higher in patients with migraine than in controls (weighted mean difference 1.12 mg/L; 95% CI 1.01-1.25 mg/L; p < 0.001). In further analysis of studies containing separate data for migraine with and without aura (n = 7), CRP values remained significantly higher in both migraineur patients with aura (n = 1939; weighted mean difference 0.88 mg/L; 95% CI 0.63-1.14 mg/L; p < 0.001) or without aura (n = 2483; weighted mean difference 1.04 mg/L; 95% CI 0.78-1.30 mg/L; p < 0.001) when compared with controls (n = 29,354). Despite a large interstudy heterogeneity (99.3%), our analysis provides evidence of a potential epidemiological association between increased concentration of CRP and migraine, thus paving the way for further clinical investigations about therapeutic agents that may contextually decrease the risk of cardiovascular disease and reduce the burden of migraine.

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Section: Overview On Epidemiological Datamentioning

confidence: 99%

Section: Overview On Epidemiological Datamentioning

confidence: 99%

C-reactive protein and migraine. Facts or speculations?

Lippi¹,

Mattiuzzi²,

Cervellin

2014

Clinical Chemistry and Laboratory Medicine

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“…Other inflammatory markers believed to be associated with vascular dysfunction are elevated in the blood of patients with migraine. It has been shown that mean values for plasma C‐reactive protein and homocysteine were higher in children with migraine than in those without headaches . In premenopausal women with migraine, particularly in those with aura, there is evidence of increased endothelial activation, a component of endothelial dysfunction, reflected by elevations in von Willebrand factor, C‐reactive protein, nitrate/nitrite, and tissue‐type plasminogen activator antigen .…”

Section: Diagnostic Molecular Markers Associated With Increased Risk mentioning

confidence: 99%

Biomarkers Associated With Migraine and Their Potential Role in Migraine Management

Durham

Papapetropoulos

2013

Headache

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The understanding of the etiology of migraine is incomplete. Although the identification and validation of biomarkers has greatly advanced diagnostic precision and measures of therapeutic efficacy in other diseases, there are no currently accepted biomarkers for chronic or episodic migraine. However, the continued investigation and identification of genetic, epigenetic, and molecular biomarkers is likely to facilitate the goal of individualizing medicine by enabling clinicians to more accurately diagnose and treat migraine and other headache disorders.

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“…Available data for children are insufficient and controversial. A large US study revealed no correlation between lipid levels and the occurrence of primary headaches in children [23]. In contrast, Glueck and Bates reported a relation between severe migraine headaches and LDL cholesterol and HDL cholesterol levels in boys with primary and familial dyslipoproteinaemias [3].…”

Section: Discussionmentioning

confidence: 95%

“…However, there are only a few studies conducted in paediatric patients. Some small clinical studies showed a relation between dyslipidaemia and migraine in children [4,5]. Recent data suggest that new potential risk factors for atherosclerosis and platelet aggregation, such as brain-derived neurotrophic factor (BDNF), sCD40L (soluble CD40 ligand), serpin E1/PAI I (endothelial plasminogen activator inhibitor) and vascular endothelial growth factor (VEGF), may also play a role in the pathogenesis of atherosclerosis and platelet aggregation [6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Sordyl

Kopyta

Sarecka-Hujar

et al. 2019

aoms

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A b s t r a c tIntroduction: Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idiopathic headaches. Material and methods: The study population comprised 65 children (39 with idiopathic headaches and 26 healthy children). Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triacylglycerol (TG) levels were measured in every patient. Brain-derived neurotrophic factor (BDNF), soluble CD40 ligand (sCD40L), endothelial plasminogen activator inhibitor (serpin E1/PAI I) and vascular endothelial growth factor (VEGF) blood level measurements were performed in 34 children. Results: Children with headaches had higher BMI z-scores (0.2 vs. -1.14; p = 0.006). TC level was lower in patients with headaches (121.04 mg/dl vs. 146.87 mg/dl, p = 0.019). No differences in concentrations of TG, HDL or LDL were found. BDNF was significantly higher in the studied group (171.57 pg/ ml vs. 64.04 pg/ml, p = 0.012). The VEGF was higher in boys with headaches than in girls (368.27 pg/ml vs. 142.86 pg/ml, p = 0.011). There were no differences in levels of VEGF, sCD40L or PAI-1 between groups. Conclusions: Children with headaches have lower total cholesterol and higher BDNF levels than controls. No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls.

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Headache and Biomarkers Predictive of Vascular Disease in a Representative Sample of US Children

Cited by 42 publications

References 44 publications

C-reactive protein and migraine. Facts or speculations?

C-reactive protein and migraine. Facts or speculations?

Biomarkers Associated With Migraine and Their Potential Role in Migraine Management

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

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