Headache and Multiple Sclerosis: A Population-Based Case-Control Study in Catania, Sicily

Nicoletti, Alessandra; Patti, Francesco; Fermo, Salvatore Lo; Liberto, Aldo; Castiglione, A.; Laisa, P; Garifoli, A.; Naia, Filippo La; Maimone, Davide; Sorbello, Veronica; Contrafatto, Donatella; Zappia, Mario

doi:10.1111/j.1468-2982.2008.01662.x

Cited by 64 publications

(52 citation statements)

References 25 publications

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“…As in the meta-analysis run in the above-mentioned studies the following values were obtained (P= 0.02; 1.14-4.58, OR =2.29). 11,12,14 The present study's results were also quite consistent with the above studies. In the present study, the association between MS and migraine was confirmed (P=0.038; OR=1.87); Also in the disjunctive analysis, a significant association was only found between MS and headache without aura (0.04 = P; 1.94 = OR).…”

Section: Discussionsupporting

confidence: 82%

“…All studies have confirmed the association between migraine and MS. 2,5,11,13 Some studies such as studies done by Vecca, Katsiari and Nicoletti did not find any significant relationship between MS and migraine with aura. 11,12,14 Conversely, the very researchers found a significant association between MS and the occurrence of migraine without aura. As in the meta-analysis run in the above-mentioned studies the following values were obtained (P= 0.02; 1.14-4.58, OR =2.29).…”

Section: Discussionmentioning

confidence: 99%

“…Similar results were also observed in Vecca and Nicoletti's studies. [10][11][12] In the study by Putzki, female to male ratio was 2.13 to 1. Corresponding to above mentioned studies, the women in the present study constituted the majority of people with MS (73.13%).…”

Section: Discussionmentioning

confidence: 99%

“…1,2,6,[8][9][10][11] In a study undertaken by Ashtary, 76% of patients with MS were female. 9 Similarly, in Ashtiani's study, 76.9% of patients with MS were female.…”

Section: Discussionmentioning

confidence: 99%

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Study relationship between multiple sclerosis and migraine

Ghoreyshi

Fattahzadeh-Ardalani

2016

Int J Res Med Sci

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Background: Each person experiences headaches in his/her life. Some studies have shown a significant relationship between Migraine and MS. In these patients there can be a variety of clinical symptoms such as muscle weakness, sensory loss, ataxia, optic neuritis. Optic neuritis in MS is a relatively common symptom that can cause blurred vision, headaches (especially frontal ones) and painful eye movements. Headache is a clinical symptom that makes people visit neurologists. There are several diagnoses for headaches including migraine. In this study, we evaluated the possibility of a significant relationship between migraine and MS. Methods: In this case-control study, 134 MS patients and 134 sex and age matched controls were selected randomly from all patients referred to hospital. Their information about MS and migraine was collected and analyzed by SPSS v.21. Results: The Mean age of cases in this study was 41.5±9.4 years. The gender of 73.13% of patients was female. In MS patients with chronic headaches, 36 people (42.9%) and in Controls 22 people (38.6%) had migraine. In this study it was found that people with MS, experience more migraine attacks compared to the controls (OR=3 and P=0.05). Further investigation showed that, unlike aura type, migraine without aura had a significant relation with the MS (OR=1.94 and P=0.04). Also, it seems that the number of migraine attacks in patients with MS is significantly more than the controls. Conclusions: Finally it seems that there is a positive association between MS and migraine. The relationship between migraine without aura and MS is obvious, but the relation between aura type and MS is not clear, yet.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…1,2,6,[8][9][10][11] In a study undertaken by Ashtary, 76% of patients with MS were female. 9 Similarly, in Ashtiani's study, 76.9% of patients with MS were female.…”

Section: Discussionmentioning

confidence: 99%

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Study relationship between multiple sclerosis and migraine

Ghoreyshi

Fattahzadeh-Ardalani

2016

Int J Res Med Sci

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“…Although a growing literature describes the frequency and impact of comorbidity in MS [2,29,30] , research regarding methods of comorbidity measurement in this population is lacking. Our findings indicate moderate or better levels of agreement between self-report and medical records for diabetes, hypertension, hyperlipidemia, thyroid disease, chronic lung disease, osteoporosis, irritable bowel syndrome, migraine, heart disease, depression, and anxiety disorders.…”

Section: Discussionmentioning

confidence: 99%

Validation of a Self-Report Comorbidity Questionnaire for Multiple Sclerosis

Horton¹,

et al. 2010

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Background/Aims: Researchers increasingly recognize the high frequency of comorbidity in multiple sclerosis (MS) and the negative impact on quality of life and disability, but little work has evaluated methods of comorbidity measurement in MS. We aimed to validate a self-report questionnaire for assessing comorbidity in MS. Methods: Patients with MS were recruited from the MS Clinic in Winnipeg, Canada and the Mellen Center (Cleveland Clinic, Cleveland, Ohio, USA) from October 2008 to 2009. Using a questionnaire, participants reported the presence or absence of 36 comorbidities, sociodemographic characteristics, and disability status. Abstractors blinded to questionnaire results collected data regarding the comorbidities of interest and their treatments. Using the medical record as the gold standard, we determined the sensitivity, specificity, positive and negative predictive values of the questionnaire data. To measure agreement we calculated kappa (ĸ) statistics. Results: We enrolled 404 participants. Agreement between self-report and medical records was high (ĸ >0.82) for diabetes and hypertension; substantial (ĸ = 0.62–0.80) for hyperlipidemia, thyroid disease, glaucoma, and lung disease; moderate (ĸ = 0.43–0.56) for osteoporosis, irritable bowel syndrome, migraine, depression, heart disease, and anxiety disorders. Agreement was slight to fair for the remaining comorbidities. Conclusions: Self-report is a valid way to capture comorbidities affecting MS patients.

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The epidemiology of primary headaches in patients with multiple sclerosis

et al. 2020

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Objective Recent studies have shown a pathophysiologic link between headache and multiple sclerosis (MS), but the prevalence of primary headaches among patients with MS differs substantially across studies. This meta‐analysis aimed to comprehensively gather available evidence to estimate the prevalence of primary headaches among patients with MS. Method We systematically searched the electronic databases including PubMed, Embase, and Scopus for cohort, case–control, cross‐sectional studies that measured the prevalence of headache among patients with MS. Two reviewers independently screened titles and abstracts to identify the eligible studies and the full texts of the included studies were reviewed. Newcastle‐Ottawa Scale (NOS) was used to assess the risk of bias of the included literatures. We then conducted a meta‐analysis using Stata Software 15.0 to calculate the pooled prevalence of headaches among patients with MS and assess the source of heterogeneity. Results We identified 16 eligible studies covering a total of 3,560 patients with MS. The pooled estimated prevalence of primary headaches among patients with MS was 56%. The statistical heterogeneity was moderate with I2 of 82.1% (p < .001). Both a visual inspection of the funnel plot and Egger’ regression tests revealed no significant publication bias (p = .44). The pooled estimated prevalence of migraine (55%) was higher in comparison with that of tension‐type headache (20%). The prevalence of migraine subtype was 16% and 10% for migraine without aura and migraine with aura, respectively. The pooled prevalence of primary headache in case–control group (57%) was approximately in line with the cross‐sectional group (56%). Conclusion The overall prevalence of primary headaches among patients with MS was considerably high. Clinical screening of headache among patients with MS will be helpful to formulate an individualized treatment plans and alleviate the physical and mental impact of the disease.

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Headache and Multiple Sclerosis: A Population-Based Case-Control Study in Catania, Sicily

Cited by 64 publications

References 25 publications

Study relationship between multiple sclerosis and migraine

Study relationship between multiple sclerosis and migraine

Validation of a Self-Report Comorbidity Questionnaire for Multiple Sclerosis

The epidemiology of primary headaches in patients with multiple sclerosis

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