Headache frequency associates with brain microstructure changes in patients with migraine without aura

Yu, Yang; Zhao, Hongru; Dai, Lingling; Su, Yunyan; Wang, Ximing; Chen, Can; Shang, Yalei; Ke, Jun; Hu, Chunhong

doi:10.1007/s11682-019-00232-2

Cited by 28 publications

(24 citation statements)

References 36 publications

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“… 16 In one previous study, we found the hippocampus volume of the healthy control (HC) group was smaller than that of the EM group, but was larger than that of the CM group. 17 This finding accorded with two cross-sectional studies suggesting an adaptive volume increase at low headache frequency and a maladaptive volume decrease at higher headache frequency, and proved the necessity to compare migraine patients of different headache frequency when investigating alterations in hippocampus-related brain circuit.…”

Section: Introductionsupporting

confidence: 72%

Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura

Zhu¹,

Dai²,

Zhao³

et al. 2021

JPR

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Neuroimaging studies on migraine have revealed structural and functional alterations in the hippocampus, a region involved in pain processing and stress response. This study was designed to investigate whether effective connectivity of this region is disrupted in migraine and relates to chronicity of this disease. Patients and Methods: In 39 episodic migraine (EM) patients, 17 chronic migraine (CM) patients, and 35 healthy controls, we investigated differences in the directional influences between the hippocampus and the rest of the brain by combining resting-state functional magnetic resonance imaging and Granger causality analysis (GCA), with bilateral hippocampus as seed regions. The associations between directional influences and the clinical variables were also examined. Results: Comparing each patient group to the control group, we found increased and decreased negative influence on the hippocampus exerted by the bilateral visual areas and right dorsolateral prefrontal cortex (dlPFC), respectively. The hippocampus showed increased positive influence on the right posterior insula and medial prefrontal cortex (mPFC), as well as increased negative influence on the left cerebellum in CM patients relative to EM patients and healthy controls. Furthermore, across all patients, the migraine frequency exhibited a positive and negative association with causal influence from the hippocampus to mPFC and left cerebellum, respectively. Conclusion: Migraine patients have abnormal effective connectivity between the hippocampus and multiple brain regions involved in the sensory and cognitive processing of pain. Disrupted directional influences to the hippocampus exerted by dlPFC and bilateral visual areas were common features of EM and CM patients. Directional influences from the hippocampus to mPFC and left cerebellum may be useful imaging biomarkers for assessing migraine frequency.

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Section: Introductionsupporting

confidence: 72%

Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura

Zhu¹,

Dai²,

Zhao³

et al. 2021

JPR

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“…Nevertheless, our findings was supported by a DTI study based on graph theory approaches by showing that excessive network integration of the HP in migraineurs predicted poor placebo effect and may contribute to the development and maintenance of persistent migraine [40]. We recently found that migraine frequency negatively associated with gray matter volume in the right HP/PHG [41]. The HP is involved in learning and memory formation, as well as pain-related attention and anxiety, and stress response [42,43].…”

Section: Discussionsupporting

confidence: 73%

Altered local and distant functional connectivity density relate to headache frequency in migraine without aura

Ke¹,

Yu²,

Zhang³

et al. 2020

Preprint

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Background Episodic migraine (EM) is associated with alterations in functional connectivity of several regions or resting-state networks, but it is not well known how large-scale functional connectivity pattern of the whole brain is affected in chronic migraine (CM). Methods Fifty-six migraineurs without aura (39 with EM, 17 with CM) and 35 healthy controls (HC) underwent clinical assessment and resting-state functional MRI. Functional connectivity density (FCD) was calculated in a voxel-wise way to examine large-scale brain network property over the whole brain. Results Compared with HC, both migraine groups showed increased local FCD in the left orbital frontal gyrus (OFG), right hippocampus/parahippocampal gyrus (HP/PHG), cerebellum, and decreased local FCD in the bilateral dorsolateral prefrontal cortex. Local FCD of the left OFG increased in CM compared to EM. In comparison with HC, EM showed increased local FCD in the left middle temporal gyrus, and CM exhibited decreased local FCD in the left sensorimotor cortex and bilateral precuneus. Furthermore, relative to HC, EM showed increased distant FCD in the right PHG while CM showed increased distant FCD in the right HP and OFG. Importantly, majority of the observed local and distant FCD alterations were associated with migraine frequency across all migraineurs. Conclusion Patients with higher migraine frequency present more extensive and pronounced functional connectivity dysfunctions in regions involved in pain processing and modulation. FCD, especially local FCD may be a sensitive biomarker for examining the neural mechanism of migraine.

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“…They proposed that this finding was suggestive of an initial adaptive plasticity that may then become dysfunctional with increased frequency (28). Yu and colleagues performed voxel-based morphometric analysis and found that the left hippocampus/parahippocampal gyrus volume of their healthy control group was smaller than that of the episodic migraine group but was larger than that of the chronic migraine group (29). Liu and colleagues conducted a review and found that “factors including headache frequency, accumulative number of migraine attacks, anxiety score, depression score, and genetic variants are related to hippocampal morphology and functional changes in people with migraine” (25).…”

Section: Discussionmentioning

confidence: 99%

Visually guided associative learning in pediatric and adult migraine without aura

et al. 2020

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Introduction The Rutgers Acquired Equivalence Test is a visually guided equivalence learning paradigm that involves rule acquisition and generalization. Earlier we found impaired performance in this paradigm among adult migraine patients without aura. The aim of the study was to investigate if similar impairments can be found already in the pediatric form of the disease and to compare the performance of the pediatric study population with that of an adult study population. We hypothesized that the deficits observed in adults would be observable already in the pediatric population. Methods Twenty-seven children and adolescents newly diagnosed with migraine without aura and 27 age- and sex-matched healthy controls were tested with the Rutgers Acquired Equivalence Test. Their performance data were compared to each other and those of an earlier adult study population involving 22 patients and 22 age- and sex-matched healthy controls. Four parameters characterizing performance in the two main phases of the paradigm were calculated for each of the four groups. Performance parameters were compared with Mann-Whitney U test. Results In contrast to the decreased performance of the adult patients in the Rutgers Acquired Equivalence Test, no significant difference was found between pediatric patients and controls in any phase of the paradigm. Conclusion Children living with migraine without aura do not exhibit the same cognitive deficits in the Rutgers Acquired Equivalence Test as their adult counterparts. It can be hypothesized that the deficit of equivalence learning is not an inherent feature of the migrainous cognitive profile, rather the result of the interference of the disease with normal development.

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Headache frequency associates with brain microstructure changes in patients with migraine without aura

Cited by 28 publications

References 36 publications

Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura

Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura

Altered local and distant functional connectivity density relate to headache frequency in migraine without aura

Visually guided associative learning in pediatric and adult migraine without aura

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