Headache in Children with Tourette Syndrome

Ghosh, Debabrata; Rajan, Prashant V.; Das, Deepanjana; Datta, Priya; Rothner, A. David; Erenberg, Gerald

doi:10.1016/j.jpeds.2012.01.072

Cited by 30 publications

(27 citation statements)

References 11 publications

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“…A recent study of Ghosh et al (2012) [104] analyzed the frequency of occurrence of headaches in children and adolescents with TS to address their possible inclusion as a comorbidity.…”

Section: Headache and Psychiatric Disorders: Anxiety And Depressionmentioning

confidence: 99%

Headache and comorbidity in children and adolescents

Arruda²,

et al. 2013

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Headache is one of the most common neurological symptom reported in childhood and adolescence, leading to high levels of school absences and being associated with several comorbid conditions, particularly in neurological, psychiatric and cardiovascular systems. Neurological and psychiatric disorders, that are associated with migraine, are mainly depression, anxiety disorders, epilepsy and sleep disorders, ADHD and Tourette syndrome. It also has been shown an association with atopic disease and cardiovascular disease, especially ischemic stroke and patent foramen ovale (PFO).

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“…A recent study of Ghosh et al (2012) [104] analyzed the frequency of occurrence of headaches in children and adolescents with TS to address their possible inclusion as a comorbidity.…”

Section: Headache and Psychiatric Disorders: Anxiety And Depressionmentioning

confidence: 99%

Headache and comorbidity in children and adolescents

Arruda²,

et al. 2013

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“…A frequent association of various allergic processes with the respiratory system and skin, and a higher frequency of migraines than in the general population have been described [5].…”

Section: Discussionmentioning

confidence: 99%

Tourette Syndrome and Non-Coeliac Gluten Sensitivity. Clinical Remission with a Gluten-Free Diet: A Description Case

M¹

2015

J Sleep Disord Ther

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Background: Tourette syndrome (TS) is a primary tic disorder, that reaches most commonly medical attention and monitoring, Its etiology remains unknow and there are scant information about the role of associated food intolerance to its presence. Methods: We analyze the case of a 13 y.o. female, with a long history of 10 years of tics and obsessivecompulsive disorder. She had a family history positive for celiac disease and we studied for her presence, determining serological markers (anti-tissue transglutaminase-2 (tTG), genetic markers of susceptibility (HLA-DQ2 and DQ8) and duodenal biopsies looking for the presence of villous atrophy and or lymphocytic enteritis. IgE specific to wheat, was also done. Results: The tTG was negative; HLA-DQ8 was positive and there was a moderate lymphocytic enteritis. IgE RAST test for wheat, was also negative. She was diagnosed of non-celiac gluten sensitivity (NCGS) and a glutenfree diet (GFD) was started. A great clinical improvement was observed in few months and after 2.5 years she remains well and completely asymtomatic of her neuro-psychiatric ailments. Conclusions: This clinical observation opens a new possibility of the existence a causal relationship between the presence of a TS in children with NCGS and by consequence the convenience to start a GFD in these patients. New studies will be needed in order to support this observation.

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“…Reports of an increased rate of allergic disorders (Chang et al, 2011; Ho et al, 1999) and elevated IgE (Finegold, 1985; Hsieh et al, 2010; Landau et al, 2012) lend support to this concept. A higher frequency of migraine, possibly associated with the presence of antiphospholipid antibodies (Toren et al, 1994), is noted in TS at rates similar to the elevated rates in SC and rheumatic fever (Barabas et al, 1984; Ghosh et al, 2012; Kwak et al, 2003; Teixeira et al, 2005). Patterns of familiality in TS also point toward the existence of an immune subset.…”

Section: Introductionmentioning

confidence: 90%

Immune-mediated animal models of Tourette syndrome

Hornig

Lipkin

2013

Neuroscience & Biobehavioral Reviews

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An autoimmune diathesis has been proposed in Tourette syndrome (TS) and related neuropsychiatric disorders such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism and anorexia nervosa. Environmental triggers including infection and xenobiotics are hypothesized to lead to the production of brain-directed autoantibodies in a subset of genetically susceptible individuals. Although much work has focused on Group A Streptococcus (GAS), the role of this common childhood infection remains controversial. Animal model studies based on immune and autoantibody findings in TS have demonstrated immunoglobulin (Ig) deposits and stereotypic movements and related behavioral disturbances reminiscent of TS following exposure to GAS and other activators of host anti-microbial responses, soluble immune mediators and anti-GAS or anti-neuronal antibodies. Demonstration of the ability to recreate these abnormalities through passive transfer of serum IgG from GAS-immunized mice into naïve mice and abrogation of this activity through depletion of IgG has provided compelling evidence in support of the autoimmune hypothesis. Immunologically-based animal models of TS are a potent tool for dissecting the pathogenesis of this serious neuropsychiatric syndrome.

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Headache in Children with Tourette Syndrome

Cited by 30 publications

References 11 publications

Headache and comorbidity in children and adolescents

Headache and comorbidity in children and adolescents

Tourette Syndrome and Non-Coeliac Gluten Sensitivity. Clinical Remission with a Gluten-Free Diet: A Description Case

Immune-mediated animal models of Tourette syndrome

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