Heal the heart through gut (hormone) ghrelin: a potential player to combat heart failure

Gupta, Shreyasi; Mitra, Amrita

doi:10.1007/s10741-020-10032-2

Cited by 8 publications

(8 citation statements)

References 250 publications

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“…The cardioprotective actions regarding cardiac hypertrophy, fibrosis, calcium handling, and cardiac remodeling following ischemic injury demonstrate that ghrelin acts on different pathways in the pathophysiology of both heart failure with preserved and reduced ejection fraction [ 182 ]. The molecular mechanisms involved are modulation of autophagy, ionotropic actions, anti-apoptotic and anti-inflammatory pathways activation, and regulation of the autonomic nervous system [ 183 ].…”

Section: Gut Molecules and Cardiovascular Diseasesmentioning

confidence: 99%

Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story

Neag

Crăciun

Buzoianu

2023

IJMS

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Atherosclerotic cardiovascular disease is the most common cause of morbidity and mortality worldwide. Diabetes mellitus increases cardiovascular risk. Heart failure and atrial fibrillation are associated comorbidities that share the main cardiovascular risk factors. The use of incretin-based therapies promoted the idea that activation of alternative signaling pathways is effective in reducing the risk of atherosclerosis and heart failure. Gut-derived molecules, gut hormones, and gut microbiota metabolites showed both positive and detrimental effects in cardiometabolic disorders. Although inflammation plays a key role in cardiometabolic disorders, additional intracellular signaling pathways are involved and could explain the observed effects. Revealing the involved molecular mechanisms could provide novel therapeutic strategies and a better understanding of the relationship between the gut, metabolic syndrome, and cardiovascular diseases.

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Section: Gut Molecules and Cardiovascular Diseasesmentioning

confidence: 99%

Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story

Neag

Crăciun

Buzoianu

2023

IJMS

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“…Both ghrelin and the GHSR1a are expressed in the myocardium. When acylated (activated) ghrelin binds to GHSR1a it activates signalling pathways associated with cardiomyocyte survival, contractility and suppression of inflammation 1 suggesting both GH dependent and independent mechanisms 2 . In patients with heart failure (HF), GH is dysregulated, with relative GH deficiency and GH resistance 3 …”

Section: Figurementioning

confidence: 99%

“…When acylated (activated) ghrelin binds to GHSR1a it activates signalling pathways associated with cardiomyocyte survival, contractility and suppression of inflammation 1 suggesting both GH dependent and independent mechanisms. 2 In patients with heart failure (HF), GH is dysregulated, with relative GH deficiency and GH resistance. 3 In the Karolinska Acyl Ghrelin Trial (ClinicalTrials.gov NCT05277415), a recent double-blind randomized trial in HF with reduced ejection fraction (HFrEF), intravenous acyl ghrelin but not placebo increased cardiac output by 28%.…”

Section: Acyl Ghrelin Infusion Increases Circulating Growth Hormone I...mentioning

confidence: 99%

Acyl ghrelin infusion increases circulating growth hormone in patients with heart failure and reduced ejection fraction

Hage,

Ståhlberg,

Thorvaldsen

et al. 2023

European J of Heart Fail

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“…Several research and observational studies suggest that ghrelin presents a myriad of cardioprotective effects through its ability to enhance cardiac contractility; to limit ischemia/reperfusion injury, cardiac cachexia, cardiac hypertrophy, and fibrosis; to lower blood pressure by the inhibition of the sympathetic nervous system; and to ameliorate the prognosis of both myocardial infarction (MI) and HF [71][72][73]. By increasing NO levels and rectifying the endothelin-1/nitric oxide imbalance, ghrelin also has a pivotal role in endothelial function by inducing anti-oxidant, anti-inflammatory, and anti-apoptotic effects [74]. Although several experimental studies have documented the cardiovascular effects of ghrelin, relatively few human clinical trials have been published to date.…”

Section: Pharmacological Therapies For Hf: Amino Acid Orexigenic Pept...mentioning

confidence: 99%

“…These significant and valuable cardiac effects, together with vascular protection, suggest that ghrelin is a promising candidate for the treatment of congestive heart failure and should be further investigated [74]. Synthetic ghrelin that replicates the actions of endogenous ghrelin is widely used for the treatment of metabolic conditions and obesity.…”

Section: Pharmacological Therapies For Hf: Amino Acid Orexigenic Pept...mentioning

confidence: 99%

Modern Approaches for the Treatment of Heart Failure: Recent Advances and Future Perspectives

et al. 2022

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Heart failure (HF) is a progressively deteriorating medical condition that significantly reduces both the patients’ life expectancy and quality of life. Even though real progress was made in the past decades in the discovery of novel pharmacological treatments for HF, the prevention of premature deaths has only been marginally alleviated. Despite the availability of a plethora of pharmaceutical approaches, proper management of HF is still challenging. Thus, a myriad of experimental and clinical studies focusing on the discovery of new and provocative underlying mechanisms of HF physiopathology pave the way for the development of novel HF therapeutic approaches. Furthermore, recent technological advances made possible the development of various interventional techniques and device-based approaches for the treatment of HF. Since many of these modern approaches interfere with various well-known pathological mechanisms in HF, they have a real ability to complement and or increase the efficiency of existing medications and thus improve the prognosis and survival rate of HF patients. Their promising and encouraging results reported to date compel the extension of heart failure treatment beyond the classical view. The aim of this review was to summarize modern approaches, new perspectives, and future directions for the treatment of HF.

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Heal the heart through gut (hormone) ghrelin: a potential player to combat heart failure

Cited by 8 publications

References 250 publications

Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story

Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story

Acyl ghrelin infusion increases circulating growth hormone in patients with heart failure and reduced ejection fraction

Modern Approaches for the Treatment of Heart Failure: Recent Advances and Future Perspectives

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