Healing and remodeling of articular incongruities in a rabbit fracture model.

Llinás, Adolfo; McKellop, Harry A.; Marshall, G. J.; Sharpe, Fiona; Kirchen, Mary E.; Sarmiento, Augusto

doi:10.2106/00004623-199310000-00012

Cited by 125 publications

(80 citation statements)

References 23 publications

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“…The surface smoothness on the high side of the offset was preserved at six weeks. All the histological signs of adaptation which have been described earlier 17 were observed.…”

Section: Resultssupporting

confidence: 64%

“…The operative technique to create the step-off has been described earlier. 17 Three groups, containing four rabbits each, were killed at 6, 12 and 24 weeks after surgery. Both knee joints were dissected free of soft tissue and the medial femoral and tibial condyles were fixed in 10% buffered formaldehyde containing 2% cetylpyridinium chloride (CPC) for 24 hours.…”

Section: Methodsmentioning

confidence: 99%

“…Previous research on full-thickness surface offsets investigated the fate of the lesion in stable knees of rabbits. These experiments focused on the effects of the size of the defect and different methods of treatment on regeneration/degeneration of the cartilage [14][15][16][17][18][19] and have…”

mentioning

confidence: 99%

“…[15][16][17][18][19] By contrast, large defects did not heal and caused severe osteoarthritis. 14,15 Minor offsets showed qualitative changes in the immunohistological detection of 3-B-3(-) and 7-D-4 chondroitin sulphate epitopes associated with the remodelling and adaptation which occurred around the defect.…”

mentioning

confidence: 99%

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Characteristics of degeneration in an unstable knee with a coronal surface step-off

Lovász

Park²,

Ebramzadeh

et al. 2001

The Journal of Bone and Joint Surgery. British volume

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T o investigate the effect of instability on the remodelling of a minor articular surface offset, we created a 0.5 mm coronal step-off of the medial femoral condyle in 12 New Zealand white rabbits and transected the anterior cruciate ligament (ACL). A control group of 12 rabbits had only ACL resection and the opposite knee was used as the non-operated control. The osteoarthritic changes at 6, 12 and 24 weeks after surgery were evaluated histologically. In addition, changes in the immunological detection of 3-B-3(-) and 7-D-4 chondroitin-6-sulphate epitopes were determined because of the previous association of such changes with repair of cartilage and early osteoarthritis.In the instability/step-off group there was rapidly progressing focal degeneration of cartilage on the high side of the defect, not seen in previous step-off studies in stable knees. The rest of the femoral condyles and the tibial plateaux of the instability/step-off group had moderate osteoarthritis similar to that of the instability group. 3-B-3(-) was detectable in the early and the intermediate stages of osteoarthritis but no staining was seen in the severely damaged cartilage zones. Immunoreactivity with 7-D-4 increased as degeneration progressed.Our findings have shown that even a minor surface offset may induce rapid degeneration of cartilage when the stability of the knee is compromised.

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“…The surface smoothness on the high side of the offset was preserved at six weeks. All the histological signs of adaptation which have been described earlier 17 were observed.…”

Section: Resultssupporting

confidence: 64%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Characteristics of degeneration in an unstable knee with a coronal surface step-off

Lovász

Park²,

Ebramzadeh

et al. 2001

The Journal of Bone and Joint Surgery. British volume

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show abstract

“…Experimental animal studies show that step-offs of 1 mm remodel but do not resolve completely. Remodelling occurs by swelling of the unloaded cartilage, bending of the unloaded cartilage fibres, and by overlapping of cartilage edges (Llinas et al, 1993;Trumble et al, 1998).…”

mentioning

confidence: 99%

Should Anatomic Reduction be Pursued in Distal Radial Fractures?

Fernández

2000

Journal of Hand Surgery

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Two articles on distal radial fractures in young adults are published in this issue of the journal. One reports the results of open reduction and internal fixation with the p-plate in a group of patients in which the majority of fractures were complex and intraarticular. The other retrospectively assessed 169 fractures with an average follow-up of 4.9 years, based on the radiographic evaluation of the patient's X-rays until discharge and on the answers provided by a patient-based subjective outcome questionnaire. My task has been to comment, criticise and analyse the findings and results reported in both articles, in order to highlight areas of uncertainty and controversy regarding the current management of fractures of the distal radius in the younger age group.

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Dynamic Compression vs. Locking Plating − Is One “Better”? A Review of Biomechanical Principles andin vitroTesting

Biedrzycki¹

2018

Locking Plates in Veterinary Orthopedics

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Healing and remodeling of articular incongruities in a rabbit fracture model.

Cited by 125 publications

References 23 publications

Characteristics of degeneration in an unstable knee with a coronal surface step-off

Characteristics of degeneration in an unstable knee with a coronal surface step-off

Should Anatomic Reduction be Pursued in Distal Radial Fractures?

Dynamic Compression vs. Locking Plating − Is One “Better”? A Review of Biomechanical Principles andin vitroTesting

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