Healing anxiety disorders with glucocorticoids

Sandi, Carmen

doi:10.1073/pnas.1103410108

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…An increase in exploratory behavior in the open field of the apparatus indicates decreased fear. This decreased fear (anxiolytic effect) could be caused by anxiolytic drugs/agents" [14]. This trend was also seen in the high dose group.…”

Section: Resultsmentioning

confidence: 62%

Excitatory Effect of Urtica dioica on Locomotor Behaviour of Mice Using the Open Field Maze Task

Izunwanne,

Mobisson,

Nwafor

et al. 2024

JOCAMR

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Introduction: It is generally believed that the presence of some neuroactive phytochemicals such as acetylcholine, histamine, serotonin, tannins etc. in Urtica dioica may yet possess the key to the management of certain neurological and behavioral conditions at an easily accessible and affordable rates. The growing acceptance of alternative medicine in Nigeria and the world at large has necessitated this research work so as to ensure that the general/consuming public is properly guided. Objective: This study was carried out to investigate the effect of administration of Urtica dioica on locomotor behavior. The amount of Urtica dioica reaching the Central Nervous System (CNS) is affected by the extent to which it is converted/stimulates any of the excitatory agents like acetylcholine in the periphery. Methods: A total of 30 apparently healthy Swiss male albino mice weighing 20-25g were used in the study. After the 14 days of acclimatization, the mice were randomly separated into three (3) groups of ten (10) animals each and were housed in separate cages. The amice in group one (1) serves as the control for the research work and were given water and normal animal feed. Group two (2) of the mice were given feed mixed 400mg/kg of the extract while group three (3) mice were given feed mixed with 800 mg/kg of the extract. The open field maze was employed for the evaluation of locomotor behavior while the extracts were mixed with the animals’ feed. So, the extracts were administered to the mice orally. The extracts were administered for a duration of 28days (4 weeks). Results: The frequency of rearing in the open field was significantly increased in the Urtica dioica fed group compared to control (p<0.05). There is also a significant increase in the frequency of Line Crosses, Centre Square Entry and Rearing in the test groups compared to control (p<0.01). At a higher dosage, the Frequency and Duration of Grooming significantly increased (p<0.05). The Frequency of Defecation also significantly increased (p<0.05). Conclusion: These results indicate that repeated administration of Urtica dioica enhances locomotory behavior in mice.

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Section: Resultsmentioning

confidence: 62%

Excitatory Effect of Urtica dioica on Locomotor Behaviour of Mice Using the Open Field Maze Task

Izunwanne,

Mobisson,

Nwafor

et al. 2024

JOCAMR

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“…However, an increase in exploratory behaviour in the light chamber (the aversive chamber) of the apparatus indicates decreased fear. This decreased fear (anxiolytic effect) could be caused by anxiolytic drugs/agents (Sandi, 2001). The hidden-platform version of the Morris Water Maze is a test of visuo-spatial learning and memory performance of which is impaired by hippocampal lesion (Chapillon and Debouzie, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effect of P-alaxin on some neurobehavioural parameters in Swiss white mice

Nku

Essien

Ime

2018

JANS

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The effect of P-alaxin on some neurobehavioural parameters was studied in Swiss white mice. 21 mice were randomly assigned to three groups (n=7) namely; control group, clinical dose group and high dose group. Animals in control group received normal rat chow and standard feed ad libitum. Animals in the clinical dose group were given P-alaxin at a dose of 0.01mg/kg body weight while animals in the high dose group were given P-alaxin at a dose of 0.02mg/kg body weight. The results obtained showed that, in the open field maze test, the clinical dose and high dose groups showed significant increase (P<0.05) in stretch attend posture compared to control. Conversely, there was a significant decrease (P<0.05) in line crossings of high and clinical dose groups when compared to control. In the light/dark transition box test, the clinical and high dose groups showed a significant decrease (P<0.05) in the frequency of line crossings when compared to control. In the morris water maze test, the high and clinical dose groups showed a significant inncrease in frequency of swimming latency when compared to control group. From the total analysis obtained, P-alaxin decreases locomotion and exploratory activities, it impairs motivation and the tendency to investigate the environment as well as reduction in visuospartial learning and memory.

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