Healing efficacy of methanol extract of leaves of Alternanthera brasiliana Kuntze in aged wound model

Abstract

The methanol extract of Alternanthera brasiliana Kuntze (Family: Amaranthaceae) leaf was investigated for its wound healing effect by excision wound model (in vivo) in aged Sprague Dawley rats. In excision wound model, compared to the control group, percent contraction of wound was signi icantly (P < 0.01) higher in A. brasilianatreated group (5% w/w ointment). The collagen, elastin, and hydroxyproline contents of the granulation tissue of A. brasiliana-treated group increased signi icantly (P < 0.01) compared to the control group, indicating better wound healing activity of the test plant. These indings were also con irmed by histopathological examination. The results suggested that methanol extract of A. brasiliana possesses signi icant wound healing potential in aged animal wound model.

Evaluation of Phytochemical Screening and Analgesic Activity of Aqueous Extract of The Leaves of <i>Microtrichia perotitii</i> Dc (Asteraceae) in Mice using Hotplate Method

“…Increase in stress tolerance capacity of the animals indicates the possible involvement of higher centre (Omeh and Ezeja, 2010). Therefore, the overall result obtained suggested that the aqueous extract of the leaves of Microtrichia perotitii had antinociceptive activity in the hotplate test that may be in part mediated by opoid receptors and therefore can relieve pain which equally justify the use of the plant for toothaches (Barau et al, 2009). …”

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

“…A standard wound of uniform 2 cm diameter was formed with the aid of a round seal [21][22][23][24] . The treatment to the excision wounds of the rats was the same as described above.…”

EXPLORATION OF HEALING PROMOTING POTENTIALS OF LEAVES OF <i>MORUS ALBA</i> L. IN ALBINO RATS

“…The thin sections were cut and stained with haematoxylin and eosin (Vinothapooshan and Sundar, 2010;Adiga et al, 2010;Barua et al, 2009) and observed under microscope for the histopathological changes such as fibroblast proliferation, collagen formation.…”