“…7, Each included study had a majority of patients with one or more comorbidity, including diabetes mellitus, end-stage renal disease, hypertension, chronic osteomyelitis, or PVD. Seventeen studies only included patients with diabetes, 4,7,14,29,35,36,39,40,43,49,[53][54][55][56]59,60,65 five only included patients with PVD, 31,34,35,52,56 and three only included patients with chronic osteomyelitis. 43,44,47 ►Table 1 describes the number of studies that included patients with each comorbidity, the most prevalent being diabetes mellitus.…”