Healing indicators after pterygium excision by optical coherence tomography

Pujol, Pere; Julio, Gemma; Barbany, Míriam; Asaad, M.

doi:10.1111/opo.12206

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…OCT images 6 months postoperatively showed well defined limbal demarcation zone in Rgroup as compared to NRgroup. Therefore, spectral domain OCT well established the 6 sequential changes in % progressive tissue recovery after pterygium excision, not only it identified earliest changes related to complete healing of corneal, conjunctival epithelium & limbal demarcation zone but also earliest changes, which were leading to pterygium recurrence (18). In our study mitomycin-C was not used, operative AS-thickness found recurrence pterygium and ultraviolet radiation: a positive correlation.…”

Section: Resultssupporting

confidence: 54%

Anterior Segment Optical Coherence Tomography Study of Pterygium in Conjunctival - Limbal Autograft Transplantation

Yadav,

Bahadur,

Bains

et al. 2023

J. Adv. Zool.

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Introduction: Progressive, gradual, non-malignant proliferation of fibro-vascular tissue, occurring due to repetitive limbal stem-cell irritation & neovascularization, is referred to as pterygium. It is widespread in equatorial regions of the world, with a prevalence of 22% over a well defined ‘pterygium belt’. pterygium excision leaving bare sclera leads to the re occurrence, where as supplementing bare sclera with conjunctival autograft reduces the recurrence up-to 6%. Objective: Assessment of pterygium thickness pre-operative ly & post-surgery keratectomy area along with graft thickness after conjunctival limbal autograft transplantation (CLAT) surgery by anterior segment optical coherence tomography (AS- OCT). Method: 50 patients with primary pterygium were distributed age wise in 4 groups of 20-39, 40-59, 60-79 & 80-99 years. Anterior segment imaging was performed with RT-vue spectral domain AS-OCT. pterygium thickness pre-operatively & keratectomy area along with autograft thickness after CLAT surgery was evaluated for a follow-up period of 3 months. Results: the pre-op pterygium & 3 months post-op keratectomy area thickness at apex for (group 1) were 854um & 573um, (group 2) were 855um & 578um, (group 3) were 859um & 574um and (group 4) were 868um & 575um. Similarly at limbus for (group 1) are 1.13um & 720um, for (group 2) are 1.14um & 725um, for (group 3) are 1.19um & 718um, for (group 4) are 1.24um & 714um. Reduction in graft thickness in 3 months follow period for (group 1) was 311um, (group 2) 304um, (group3) 303um & (group 4) 313um respectively. Conclusions: CLAT ascertains to be the ideal treatment modality for pterygium management in terms of decreasing the complications & recurrence rate. Also, AS-OCT is the optimal investigating modality in assessment of pterygium before & after CLAT surgery.

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Section: Resultssupporting

confidence: 54%

Anterior Segment Optical Coherence Tomography Study of Pterygium in Conjunctival - Limbal Autograft Transplantation

Yadav,

Bahadur,

Bains

et al. 2023

J. Adv. Zool.

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“…Even though sensitivity is decreased in pterygium-affected corneas [15,16], no previous investigations have studied how corneal sensitivity is related to lesions in the corneal nerve fibers in patients with pterygium. Moreover, several studies have reported that corneal sensitivity recovers before reinnervation after corneal surgery [26,27]. erefore, in the present study, we investigated both the corneal subbasal nerve plexus and corneal sensitivity to determine whether functional changes are related to any anatomical modification.…”

Section: Introductionmentioning

confidence: 93%

Corneal Reinnervation and Sensitivity Recovery after Pterygium Excision

Zhao

Zhang

Liang

et al. 2020

Journal of Ophthalmology

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Purpose. To evaluate changes in corneal sensitivity and subbasal nerve density after pterygium excision. Methods. This prospective trial included 22 eyes with nasal primary pterygium and 18 controls. Corneal sensitivity was evaluated using a Cochet–Bonnet esthesiometer in the nasal, superior, temporal, inferior, and center quadrants of the cornea before surgery and 10 days, 1 month, and 3months after surgery. The central cornea was analyzed using in vivo confocal microscopy (IVCM) before surgery and 1 and 3 months after surgery. Subbasal nerve density and other nerve parameters were analyzed using NeuronJ. Nerve tortuosity was evaluated and graded in individual IVCM scans. The tear film break-up time (TBUT) test and Schirmer’s test were performed before surgery, as well as 1 and 3 months after surgery. All the same tests were performed in the controls. Results. All affected eyes showed a significant increase in corneal sensitivity in the nasal corneal quadrant after surgery when compared with preoperative data (F = 37.3; P<0.01). Compared with controls, pterygium patients demonstrated decreased corneal subbasal nerve density (P<0.01), fewer nerve trunks (P<0.01), and fewer nerve branches (P<0.05). However, an increased central corneal subbasal nerve density was observed 1 month after surgery compared with preoperative data, after which the density became stable (F = 9.62; P<0.01). Nerve tortuosity showed no difference between the two groups or across different time points in patients. Similarly, patients with pterygium demonstrated a decrease in TBUT (P<0.01) when compared with controls. A tendency toward increase was observed in the TBUT test after pterygium excision (F = 2.873; P=0.07). However, no difference was observed in Schirmer’s test. Conclusion. Pterygium patients demonstrated deteriorated corneal subbasal nerve fibers when compared with healthy controls in terms of nerve length, nerve trunks, and nerve branches. Therefore, pterygium excision improves corneal sensitivity and increases corneal subbasal nerve density.

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“…Richdale et al 13 provide strong evidence supporting the use of OCT to measure lens thickness in vivo, providing a foundation for the potential clinical use of OCT for this purpose. In addition, Pujol et al 14 suggest that OCT imaging of the corneal epithelium and limbus can predict healing success in patients following pterygium excision.…”

mentioning

confidence: 99%