1997
DOI: 10.1006/jsre.1997.5158
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Healing Mechanisms of High-Porosity PTFE Grafts: Significance of Transmural Structure

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Cited by 13 publications
(11 citation statements)
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“…To seed BMCs in ePTFE vascular prostheses stably, high porosity (60 to 90 m and more; fibril length) is thought to be advantageous for endothelialization in vivo, because the anchoring of seeded cells and the capillary ingrowth from perigraft tissue are likely to occur. [11][12][13] Hence, in this study, we chose highporosity ePTFE (90 m; fibril length) as a scaffold and were able to succeed in expressing recombinant proteins. This result may be consistent with the work of Noishiki et al 4 demonstrating that BMC-seeded high-porosity vascular prosthesis exhibited autocrine function of angiogenic factor.…”
Section: Discussionmentioning
confidence: 99%
“…To seed BMCs in ePTFE vascular prostheses stably, high porosity (60 to 90 m and more; fibril length) is thought to be advantageous for endothelialization in vivo, because the anchoring of seeded cells and the capillary ingrowth from perigraft tissue are likely to occur. [11][12][13] Hence, in this study, we chose highporosity ePTFE (90 m; fibril length) as a scaffold and were able to succeed in expressing recombinant proteins. This result may be consistent with the work of Noishiki et al 4 demonstrating that BMC-seeded high-porosity vascular prosthesis exhibited autocrine function of angiogenic factor.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, the incorporation of designed porosity into a synthetic scaffold is essential for rapid tissue regeneration, both in artificial and hybrid organs. For example, the fate of implanted artificial grafts has been discussed over the years in terms of porosity [1][2][3][4][5][6][7][8][9][10][11][12][13] : Greater porosity enhances tissue regeneration via transmural cell migration and proliferation and subsequent production of extracellular matrix. [10][11][12][13][14][15] These morphogenetic events eventually lead to a higher patency rate.…”
Section: Introductionmentioning
confidence: 99%
“…Sixty vascular implants in Sprague-Dawley rats and twenty tissue replacements in New Zealand rabbits reacted similarly with respect to cellular and vascular colonization, collagenization, foreign body reaction and final encapsulation. The healing mechanisms of implanted prostheses were also described by Tsuchida et al (1997), who implanted four types of PTFE grafts in both carotid and femoral arteries of dogs. The grafts were different with respect to porosity and were not preclotted or coated prior to implantation.…”
Section: Healingmentioning
confidence: 95%
“…It was concluded that the primary mechanism for endothelialization is ingrowth from the anastomoses (edges) of the graft, rather than transmural tissue migration or deposition of a multipotential cell from the blood. Transmural fibrocapillary incorporation did, however, support endothelial attachment and in-growth from the anastomoses (Tsuchida et al, 1997).…”
Section: Healingmentioning
confidence: 98%