Healing of Apical Periodontitis in Patients with Inflammatory Bowel Diseases and under Anti–tumor Necrosis Factor Alpha Therapy

Cotti, Elisabetta; Mezzena, Silvia; Schirru, Elia; Ottonello, Olimpia; Mura, Michela; Ideo, Francesca; Susnik, Marta; Usai, Paolo

doi:10.1016/j.joen.2018.09.004

Cited by 33 publications

(38 citation statements)

References 48 publications

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“…It has been reported that patients undergoing such therapy are associated with faster healing of AP as compared to the control group. 17 The increased level of TNF-α in the AS patients would have been reduced by anti-TNF-α therapy, and this might have resulted in unchanged healing outcomes, similar to those of the control group patients. However, we must take into account several immunologic factors that are related to the process of AS.…”

Section: Discussionmentioning

confidence: 96%

Association of ankylosing spondylitis with radiographically and clinically diagnosed apical periodontitis: A cross-sectional study

2020

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Background. There are no studies evaluating the possible association between ankylosing spondylitis (AS) and apical periodontitis (AP). Objectives. The aim of the present cross-sectional study was to investigate the possible association between AS and AP. Material and methods. Fifty patients diagnosed with AS, receiving treatment at the Rheumatology Clinic in Erzurum, Turkey, were included in the experimental group. Another 50 age-and gender-matched individuals without any history of systemic disease were included in the study as the control group. All patients were examined radiographically and clinically to diagnose the presence of AP. The following data was recorded for all patients: the smoking habit, the number of teeth present, the number of teeth with AP, the number of root canal-treated (RCT) teeth, and the number of RCT teeth with AP. Results. There were 1,283 teeth in the AS group and 1,305 in the control group. There was a significant association between teeth with AP and AS, as the prevalence of teeth with AP was significantly lower in the control group (1.3%) than in the AS group (2.9%) (OR (odds ratio) = 2.250; p = 0.005). There was no statistically significant difference between the groups in terms of the number of RCT teeth and RCT teeth with AP (p > 0.05). Conclusions. Ankylosing spondylitis is significantly associated with an increased prevalence of AP. It can be concluded that patients with AS can be more prone to develop AP. However, AS does not reduce the success rate of endodontic treatment, because there was no significant difference between the AS and control groups in terms of RCT teeth with AP.

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Section: Discussionmentioning

confidence: 96%

Association of ankylosing spondylitis with radiographically and clinically diagnosed apical periodontitis: A cross-sectional study

2020

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“…This has also happened recently with IBD. 15,29 Even though the etiology of IBD is not exactly known, it has been shown that both genetic and environmental factors play a role in its pathogenesis. 30 The characteristic intestinal inflammation would be produced by an inadequate immune response of the intestinal mucosa against the luminal antigens in a host with genetic susceptibility, resulting in an imbalance of pro-inflammatory and anti-inflammatory factors.…”

Section: Discussionmentioning

confidence: 99%

“…36 A previous study has shown that periapical lesions of patients with IBD taking biologic medications, such as anti-TNFα, healed faster after nonsurgical endodontic treatment compared with healthy control subjects. 29 The authors attribute this fact to a possible beneficial effect for the endodontic treatment of biological drugs. 29 Nevertheless in the present study, only 3 of the IBD patients were taken adalimubad or infliximab, 2 anti-TNFα medications.…”

Section: Discussionmentioning

confidence: 99%

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High Prevalence of Apical Periodontitis in Patients With Inflammatory Bowel Disease: An Age- and Gender- matched Case-control Study

Borrego¹,

Segura-Sampedro

Martín-González

et al. 2019

Inflammatory Bowel Diseases

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“…The IL-17/IL-23 axis appears to play critical roles in IBD and periodontitis by inducing and regulating the innate immune response to the tissues and pathogens ( 56 , 57 ). A clinical control trial showed that periodontitis patients with concurrent IBD treated with anti-tumor necrosis factor alpha (anti-TNF-α) therapy had a higher probability of healing than did those managed without anti-TNF-α therapy ( 58 ). Transcriptomic analysis of periodontitis identified a special upregulated gene, pleckstrin, which was overexpressed in patients with UC and other chronic inflammatory diseases, supporting the hypothesis of a network between periodontitis and IBD ( 59 ).…”

Section: Discussionmentioning

confidence: 99%

Co-pathogens in Periodontitis and Inflammatory Bowel Disease

et al. 2021

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Localized inflammatory lesions in one area of the body may affect other distant organs through various modes of transmission thus initiating secondary inflammatory infections. Periodontal disease (PD) and inflammatory bowel disease (IBD) have been shown to coexist. Periodontitis is a multifactorial inflammatory disease, and dental plaque is considered to be the initial risk factor. Individuals with genetic susceptibility are more likely to develop periodontitis when exposed to external stimuli. IBD is affected by host genetics, immunoregulation, daily diet, and the gut microbiota, and its risk factors appear to be shared with those of PD. However, the key etiologies of both diseases remain unclear, thus hindering the exploration of possible links between IBD and PD. Recent studies and systematic reviews have focused on evidence-based statistics of the prevalence and clinical manifestations of both diseases, but discussions of the microbial etiological correlation between periodontitis and intestinal inflammation are scarce. Here, we summarize the potential common pathogenic microorganisms that may serve as bridges between the two diseases. Studies have shown that invasive microorganisms such as Porphyromonas gingivalis, Fusobacterium nucleatum, Klebsiella spp. and Campylobacter spp. play key roles in the comorbidity of PD and IBD.

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Healing of Apical Periodontitis in Patients with Inflammatory Bowel Diseases and under Anti–tumor Necrosis Factor Alpha Therapy

Cited by 33 publications

References 48 publications

Association of ankylosing spondylitis with radiographically and clinically diagnosed apical periodontitis: A cross-sectional study

Association of ankylosing spondylitis with radiographically and clinically diagnosed apical periodontitis: A cross-sectional study

High Prevalence of Apical Periodontitis in Patients With Inflammatory Bowel Disease: An Age- and Gender- matched Case-control Study

Co-pathogens in Periodontitis and Inflammatory Bowel Disease

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