2004
DOI: 10.1007/s10350-003-0085-7
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Healing of Colon Anastomoses Covered With Fibrin Glue After Immediate Postoperative Intraperitoneal Administration of 5-Fluorouracil

Abstract: The immediate postoperative, intraperitoneal administration of 5-FU inhibited wound healing. However, when the colonic anastomoses were covered with fibrin glue, the injection of 5-FU had no adverse effects on the healing of the anastomoses.

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Cited by 57 publications
(75 citation statements)
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“…Colonic bursting pressure is a sign of the mechanical endurance of the anastomosis 35 . In a study by Xiao H. et al 36 the impact of a carboxymethylchitosan-carboxymethylcellulose (CMCH-CMC) film applied to the surface of anastomosis on wound healing was explored in rats.…”
Section: Comparison Of Chitosan and Control Groups Three And Seven Damentioning
confidence: 99%
“…Colonic bursting pressure is a sign of the mechanical endurance of the anastomosis 35 . In a study by Xiao H. et al 36 the impact of a carboxymethylchitosan-carboxymethylcellulose (CMCH-CMC) film applied to the surface of anastomosis on wound healing was explored in rats.…”
Section: Comparison Of Chitosan and Control Groups Three And Seven Damentioning
confidence: 99%
“…Injections were repeated until the 6th postoperative day (a total of 7). In previous studies, the number of injections ranged from 2 to 7 after surgery [5,6,7,8,10,17]. We chose the maximum number of injection to allow for an adequate contrast in collagen regeneration rates between groups C and M. Because of this, we accepted a higher mortality rate for group M.…”
Section: Methodsmentioning
confidence: 99%
“…Immediately after operation, 20 mg/kg 5-FU with saline (concentration of 5 mg/ml) was injected intraperitoneally in the M group rats and was continued for 7 days, which is a dosage used in previous studies [5,6,7,8]. In the control group, normal saline was administered at 1 ml/100 mg/day.…”
Section: Methodsmentioning
confidence: 99%
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“…O adesivo cirúrgico BioGlue poderia ser útil nas anastomoses digestivas, promovendo uma barreira física em torno das mesmas, diminuindo as taxas de deiscência no período pós-operatório, aumentando a resistência mecânica e a pressão de ruptura 21 . A principal indicação do adesivo cirúrgico BioGlueÒ tem sido na hemostasia adjuvante aos méto-dos padrões (tais como suturas, grampeadores), nas cirurgias abertas de reparo de grandes vasos (tais como aorta, femoral e carótida) em pacientes adultos 21 . Não identificamos na literatura pesquisada, estudos avaliando os efeitos dos adesivos teciduais à base de albumina-glutaraldeido nas anastomoses colônicas.…”
Section: Introductionunclassified