Healing of localized gingival recessions treated with a coronally advanced flap alone or combined with an enamel matrix derivative and a porcine acellular dermal matrix: a preclinical study

Abstract

The present results suggest that the combination of EMD and PADM in conjunction with CAF may represent a promising approach for treating single Miller class II gingival recessions.

Extracellular matrix‐based scaffolding technologies for periodontal and peri‐implant soft tissue regeneration

“…58,59 Therefore, PADM serves as a threedimensional (3D) matrix, promoting the proliferation of fibroblasts and endothelial cells and supporting a fast revascularization of its structure. 58,59 Therefore, PADM serves as a threedimensional (3D) matrix, promoting the proliferation of fibroblasts and endothelial cells and supporting a fast revascularization of its structure.…”

“…58,59 Therefore, PADM serves as a threedimensional (3D) matrix, promoting the proliferation of fibroblasts and endothelial cells and supporting a fast revascularization of its structure. 59 Figure 4 showed two clinical cases in which PADM was used for the treatment of soft tissue deficiencies at tooth and implant sites. 59 Figure 4 showed two clinical cases in which PADM was used for the treatment of soft tissue deficiencies at tooth and implant sites.…”

“…Porcine-derived acellular dermal matrix (PADM: Mucoderm) † is a CM obtained from porcine dermis after a multi-step process aimed at removing all the antigenic components. 58,59 Therefore, PADM serves as a threedimensional (3D) matrix, promoting the proliferation of fibroblasts and endothelial cells and supporting a fast revascularization of its structure. 58,60 The use of PADM has been suggested as a carrier for enamel matrix derivatives in the treatment of gingival recessions, 59 where histological evidence of periodontal regeneration was observed.…”

Treatment of multiple maxillary adjacent class I and II gingival recessions with modified coronally advanced tunnel and a new xenogeneic acellular dermal matrix

“…A recent in vitro study has shown good biocompatibility for PADM with regard to endothelial progenitor cells (EPC), and reflects high EPC viability and migration ability without any cytotoxic or apoptotic effects on the investigated progenitor cell lineage . This PADM can promote growth and proliferation of human gingival fibroblasts, osteoblasts, and endothelial cells in vitro while in vivo findings have revealed that PADM is capable of significant revascularization of its collagen structure during the early healing period …”

“…13 This PADM can promote growth and proliferation of human gingival fibroblasts, osteoblasts, and endothelial cells in vitro 13,14 while in vivo findings have revealed that PADM is capable of significant revascularization of its collagen structure during the early healing period. 15 A very recent case series has evaluated the outcomes in twelve patients presenting at least two adjacent Miller Class I or II gingival recessions treated with MCAT in conjunction with PADM and shown that this procedure may be clinically successful. 16 Overall, the available data appear to suggest that this newly developed PADM might represent an alternative to CTG, thus warranting further investigation particularly when treating cases of multiple adjacent gingival recessions.…”