Healing of pulp exposures: an ultrastructural study

Abstract

The fine structure of tissue changes during the first 14 days following pulp exposure and capping with a hard setting Ca(OH)2 cement has been studied. The early changes included hemorrhage and moderate inflammation which were largely resolved during the first week. During the second week differentiation of cells occurred at the wound surface. These cells had the characteristic features of odontoblasts and formed a predentin-like collagen matrix. The capping material was closely adapted to cellular structures at the wound surface or to the predentin-like matrix at all observation periods. Dentin fragments displaced into the pulp tissue during cavity preparation, acted as sites for pulp stone formation.

Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide

“…The ultimate goal of vital pulp therapy is to induce the dentinogenic potential of pulp cells and consequently promote the formation of dentinal bridge [37][38][39] . Therefore, we investigated whether the tested materials promote odontoblastic/osteoblastic differentiation of hpDPCs, as evidenced by the formation of mineralization nodules and increased expression of odontogenic/osteogenic-related markers such as DSPP and ON.…”

Scaffolds in Regenerative Endodontics: A Review.

“…In pulp-exposed teeth, dentin chips have been found to stimulate reparative dentin bridge formation [14] . Dentin chips may provide a matrix for pulp stem cell attachment [15] and also be a reservoir of growth factors [16] . The natural reparative activity of pulp stem cells in response to dentin chips provides some support for the use of scaffolds to regenerate the pulp dentin complex.…”

Management of the deep carious lesion and the vital pulp dentine complex

“…It has been shown that dentine chips inadvertently pushed into the pulp tissue cause severe inflammatory reaction, which can lead to pulp necrosis. 18,19 It also removes superficially contaminated pulpal tissue.…”