1989
DOI: 10.1016/0016-5085(89)90649-5
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Healing of severe perineal and cutaneous Crohn's disease with hyperbaric oxygen

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Cited by 97 publications
(55 citation statements)
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“…In view of the various positive therapeutic effects of HBO, it was also used for patients suffering from severe perianal Crohn's disease (2,(41)(42)(43)(44). Although the exact mechanism is not known well, the possible models of action include a decrease in oxidative stress and inhibition of proinflammatory cytokines.…”
Section: Discussionmentioning
confidence: 99%
“…In view of the various positive therapeutic effects of HBO, it was also used for patients suffering from severe perianal Crohn's disease (2,(41)(42)(43)(44). Although the exact mechanism is not known well, the possible models of action include a decrease in oxidative stress and inhibition of proinflammatory cytokines.…”
Section: Discussionmentioning
confidence: 99%
“…15 Two reports suggested a beneficial effect of hyperbaric oxygen in 8 patients. 16,17 Anal surgery may be considered for fissures unresponsive to medical treatment. 2,7,18 Overall, these results remain difficult to interpret because of small sample sizes and the lack of a control arm.…”
mentioning
confidence: 99%
“…Fistulae are proposed to persist due to ongoing ischemia and persistent colonization with anaerobic microorganisms [22]. HBOT is a novel treatment targeting anaerobic bacteria colonizing CD fistulae.…”
Section: Discussionmentioning
confidence: 99%