Healing potential of platelet rich fibrin in impacted mandibular third molar extraction sockets

Abstract

Background:Healing of both hard and soft tissues have become one of the great challenges, faced in clinical research in development of bioactive surgical additives responsible for regulating inflammation and increasing healing. Platelet-rich fibrin (PRF) represents a new step in the platelet gel therapeutic concept with simplified processing minus artificial biochemical modification.Aims and Objectives:The aim of this study is to evaluate the effectiveness of PRF on soft-tissue healing and bone tissue healing in terms of postoperative pain, postoperative swelling, soft tissue healing, and the quality of bone healing at the mandibular third molar socket.Materials and Methods:A clinical study will be done on patients reporting to the Department of Oral and Maxillofacial Surgery in Government Dental College, Srinagar, requiring disimpaction of bilateral mesioangular impacted mandibular third molars in 60 patients.Results:The present prospective clinical study evaluates the effect of PRF in healing of mandibular third molar extraction sockets. There was no difference in the age gender and type of impaction between the two groups as the mean postoperative pain score (visual analog scale) was lower for the PRF group (Group A) at all points of time when compared with the control (Group B), and this was statistically significant (P < 0.05). The mean percentage swelling was lower for the PRF group (Group A) at all points of time when compared with the control (Group B). Evaluating the effect of treatments (with or without PRF) on lamina dura score shows that in both the groups at different time periods, significant (P < 0.001) difference was observed on lamina dura score.Conclusion:The results of the present study suggest that application of autologous PRF gel has a beneficial effect on the healing of extraction sockets after third molar surgery.

Platelet-rich fibrin for hard- and soft-tissue healing in mandibular third molar extraction socket

“…Dar et al . [ 17 ] conducted a similar study as ours comparing hard- and soft-tissue healing potential of PRF in mandibular third molar extraction socket in terms of pain, swelling, periodontal health, and bone healing. In contrast to our study with a follow-up period of 6 months, a postoperative clinical assessment was done for 3 months only by Dar et al .…”

Comparison of the Postoperative Effects of Local Antibiotic versus Systemic Antibiotic with the Use of Platelet-Rich Fibrin on Impacted Mandibular Third Molar Surgery: A Randomized Split-Mouth Study

“…In our study, PRF with or without antibiotics was used in the tooth socket. Beneficial results regarding the effects of PRF on wound healing have been reported previously; moreover, use of PRF can decrease the incidence of bacterial infections, such as osteomyelitis, following surgery, which are commonly reported following third molar extractions [ 22 – 26 ].…”

The Effectiveness of Advanced Platelet-Rich Fibrin in comparison with Leukocyte-Platelet-Rich Fibrin on Outcome after Dentoalveolar Surgery

“…Autograft is associated with high degree of donor site morbidity, and allograft is associated with a risk of disease transmission. As such, clinicians have an interest in autologous materials, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) [ 13 ]. The main key to the healing process is the presence of adequate growth factors, which are found in platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) [ 12 ].…”

“…The use of a PRF membrane in a postextraction socket was confirmed to aid in local soft and hard tissue healing and diminishes the postoperative pain response [ 1 , 13 , 14 , 20 ]. The effectiveness of leukocyte-platelet-rich fibrin (L-PRF) is at the same level as osseous substitutes, but without having their disadvantages, which includes remaining graft particles and high cost.…”

“…Fibrin gels provide a scaffold for cell growth and a preferable environment for osteoblastic differentiation; PRF facilitates bone regeneration by space production through its strong fibrin network [19]. e use of a PRF membrane in a postextraction socket was confirmed to aid in local soft and hard tissue healing and diminishes the postoperative pain response [1,13,14,20]. e effectiveness of leukocyte-platelet-rich fibrin (L-PRF) is at the same level as osseous substitutes, but without having their disadvantages, which includes remaining graft particles and high cost.…”