Healing power of honey

Leal, Walter S.

doi:10.1073/pnas.1306617110

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…The major component of honey is a complex mixture of sugars such as glucose, fructose and sucrose with small amount of other constituents including minerals, proteins, amino acids, enzymes, organic acids, vitamins, phenolic compounds [2]. For centuries, honey has been used for nutrition in different cultures and it has also been used as a traditional medicine due to its healing properties [3]. It has been reported to be effective in the treatment of gastrointestinal disorders [4], wounds and burns healing [5], asthma [6], cataracts [7], [8] and cancer [9].…”

Section: Introductionmentioning

confidence: 99%

Gelam Honey Attenuates Carrageenan-Induced Rat Paw Inflammation via NF-κB Pathway

et al. 2013

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The activation of nuclear factor kappa B (NF-κB) plays a major role in the pathogenesis of a number of inflammatory diseases. In this study, we investigated the anti-inflammatory mechanism of Gelam honey in inflammation induced rats via NF-κB signalling pathway. Rats paw edema was induced by subplantar injection of 1% carrageenan into the right hind paw. Rats were pre-treated with Gelam honey at different doses (1 or 2 g/kg, p.o.) and NSAID Indomethacin (10 mg/kg, p.o.), in two time points (1 and 7 days). Our results showed that Gelam honey at both concentrations suppressed the gene expressions of NF-κB (p65 & p50) and IκBα in inflamed rats paw tissues. In addition, Gelam honey inhibited the nuclear translocation and activation of NF-κB and decreased the cytosolic degradation of IκBα dose dependently in inflamed rats paw tissues. The immunohistochemical expressions of pro-inflammatory mediators COX-2 and TNF-α were also decreased in inflamed rats paw tissues when treated with Gelam honey. The results of our findings suggest that Gelam honey exhibits its inhibitory effects by attenuating NF-κB translocation to the nucleus and inhibiting IκBα degradation, with subsequent decrease of inflammatory mediators COX-2 and TNF-α.

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Section: Introductionmentioning

confidence: 99%

Gelam Honey Attenuates Carrageenan-Induced Rat Paw Inflammation via NF-κB Pathway

et al. 2013

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“…Insects negatively affect human society when they become agricultural pests that damage our crops and stored products or vectors of diseases that cause tragic human suffering and death [1,2,3]. With odorant receptors (ORs) housed in neurons on the antennae and other sensory organs, they perceive the world through small molecules like pheromones, attractants, and other odorants, which are essential for their success and survival [2].…”

Section: Introductionmentioning

confidence: 99%

“…With odorant receptors (ORs) housed in neurons on the antennae and other sensory organs, they perceive the world through small molecules like pheromones, attractants, and other odorants, which are essential for their success and survival [2]. Their sophisticated olfactory system may become an Achilles’ heel once we gain a better understanding of the molecular basis of odorant and OR interactions and lay the foundation for the rationale design of eco-friendly, green chemicals for controlling populations of insects of medical importance and agricultural pests while preserving beneficial insects [3]. …”

Section: Introductionmentioning

confidence: 99%

Probing insect odorant receptors with their cognate ligands: Insights into structural features

Leal

2013

Biochemical and Biophysical Research Communications

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Oodorant receptors (ORs) are essential for insect survival in the environment and thus are ideal molecular targets for the design of insect-inspired modern green chemicals to control populations of agricultural pests and insects of medical importance. Although insect ORs are known for more than a decade, their structural biology is still in its infancy. Here, we unravel the first structural features of ORs from the malaria mosquito, the Southern house mosquito and the silkworm moth. The second extracellular loops (ECL-2s) of their predicted structures are much longer than ECL-1s and ECL-3s. The 27 amino-acid-residue-long of the ECL-2s in mosquito and the 43 amino-acid-residue-long ECL2s in moth ORs are well-conserved. About one-third of the residues are identical, including 3-4 Pro residues. Thorough examination of well-conserved residues in these structures, by point mutation and functional assay with the Xenopus oocyte recording system, strongly suggest that these “loops” include three β-turns and some degree of folding. In the Southern house mosquito three Pro residues in ECL-2 are essential for full activation of the receptor, which is finely tuned to the oviposition attractant 3-methylindole. Additionally, the “corner residues” of prolines, including Gly, Tyr, and Leu are functionally important thus suggesting that turns are stabilized not only by backbone hydrogen bonds, but also by side-chain interactions. Examination of ECL-2s from a distant taxonomical group suggests these ECL-2 loops might be functionally important in all insect ORs. Two of the four Pro residues in the predicted ECL-2 of the bombykol receptor in the silkworm moth, BmorOR1, are essential for function. Experimental evidence indicates that these loops may not be specificity determinants, but they may form a cover to the yet-to-be-identified membrane embedded binding cavities of insect ORs.

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“…Varroa destructor or Nosema ceranae), which, in turn, can feedback to exacerbate nutritional stress [19][20][21]. Good nutrition can also aid in pesticide detoxification [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Rising atmospheric CO₂is reducing the protein concentration of a floral pollen source essential for North American bees

Ziska

Pettis²,

Edwards

et al. 2016

Proc. R. Soc. B.

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At present, there is substantive evidence that the nutritional content of agriculturally important food crops will decrease in response to rising levels of atmospheric carbon dioxide, C a . However, whether C a -induced declines in nutritional quality are also occurring for pollinator food sources is unknown. Flowering late in the season, goldenrod (Solidago spp.) pollen is a widely available autumnal food source commonly acknowledged by apiarists to be essential to native bee (e.g. Bombus spp.) and honeybee (Apis mellifera) health and winter survival. Using floral collections obtained from the Smithsonian Natural History Museum, we quantified C a -induced temporal changes in pollen protein concentration of Canada goldenrod (Solidago canadensis), the most widespread Solidago taxon, from hundreds of samples collected throughout the USA and southern Canada over the period 1842-2014 (i.e. a C a from approx. 280 to 398 ppm). In addition, we conducted a 2 year in situ trial of S. canadensis populations grown along a continuous C a gradient from approximately 280 to 500 ppm. The historical data indicated a strong significant correlation between recent increases in C a and reductions in pollen protein concentration (r 2 ¼ 0.81). Experimental data confirmed this decrease in pollen protein concentration, and indicated that it would be ongoing as C a continues to rise in the near term, i.e. to 500 ppm (r 2 ¼ 0.88). While additional data are needed to quantify the subsequent effects of reduced protein concentration for Canada goldenrod on bee health and population stability, these results are the first to indicate that increasing C a can reduce protein content of a floral pollen source widely used by North American bees.

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Healing power of honey

Cited by 5 publications

References 5 publications

Gelam Honey Attenuates Carrageenan-Induced Rat Paw Inflammation via NF-κB Pathway

Gelam Honey Attenuates Carrageenan-Induced Rat Paw Inflammation via NF-κB Pathway

Probing insect odorant receptors with their cognate ligands: Insights into structural features

Rising atmospheric CO₂is reducing the protein concentration of a floral pollen source essential for North American bees

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Healing power of honey

Cited by 5 publications

References 5 publications

Gelam Honey Attenuates Carrageenan-Induced Rat Paw Inflammation via NF-κB Pathway

Gelam Honey Attenuates Carrageenan-Induced Rat Paw Inflammation via NF-κB Pathway

Probing insect odorant receptors with their cognate ligands: Insights into structural features

Rising atmospheric CO2is reducing the protein concentration of a floral pollen source essential for North American bees

Contact Info

Product

Resources

About

Rising atmospheric CO₂is reducing the protein concentration of a floral pollen source essential for North American bees