Health and Bioactive Compounds of Fermented Foods and By-Products

Carvalho, Anna Paula Azevedo de; Conte-Junior, Carlos Adam

doi:10.3390/fermentation10010013

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Fermented foods contain a variety of bioactive compounds that have therapeutic effects, especially for metabolic disorders [ 9 ]. These ingredients exhibit various beneficial activities such as lipid lowering, blood pressure lowering, thrombolysis, anti-mutation, immune stimulation, and antibacterial and anti-hair loss effects [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Obesity Properties of Blackberries Fermented with L. plantarum JBMI F5 via Suppression of Adipogenesis Signaling Mechanisms

Park,

Kim,

Lee

et al. 2024

IJMS

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Blackberries (Rubus fruticosus), which are known to include a variety of bioactive substances, have been extensively studied for their antioxidant properties. Blackberries possess multiple health beneficial effects, including anti-inflammation, anti-atherosclerosis, anti-tumor and immunomodulatory activity. However, the potential biological effects and precise molecular mechanisms of the fermented extracts remain largely unexplored. In this research, we demonstrate the effect of blackberries fermented with Lactobacillus for addressing obesity. We investigated the effect of blackberries fermented by Lactobacillus on mice fed a high-fat (60% kcal) diet for 12 weeks. Fermented blackberry administration reduced the body weight and epididymal fat caused by a high-fat diet compared to the obese group. The triglyceride and total cholesterol, which are blood lipid indicators, and the levels of leptin, which is an insulin resistance indicator, were significantly increased in the obese group but were significantly decreased in the fermented blackberries-treated group. Additionally, the expression of adipogenesis marker proteins, such as CEBPα, PPAR-γ and SREBP-1, was significantly increased in the obese group, whereas it was decreased in the fermented blackberries-treated group. These results suggest that fermented blackberries have a protective effect against high-fat-diet-induced obesity by inhibiting adipogenesis and are a potential candidate for the treatment of obesity.

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Section: Introductionmentioning

confidence: 99%