The purpose of the present study was to investigate the impact of selected demographic factors on perceptions of office workers regarding the management of health and safety in the office work place. For the data collection it was used a scale validated with a sample of 155 office employees. The final sample of the study was 301 subjects from three large Ministries in the Athens region of Greece, selected randomly. Exploratory factor analysis revealed four factors. A further comparison of the health and safety scale factors toward gender, marital status, working hours, monitoring or not seminars related to workplace safety and involvement or not in accidents in the office revealed that: (a) The male employees had more positive perceptions than their female counterparts (t = 2.62, p <0.010). (b) Positive perceptions showed and those who had attended seminars on safety and those who were not involved in office accidents (t = 2.16, p <0.032 and t = -2.19, p <0.033), respectively. (c) It was also founded that men had more positive perceptions than women in the factor workplace environmental conditions (t = 2.40, p <0.018), while employees who had attended seminars on safety had a higher score on the factor health and safety issues in the office in comparison with their colleagues who did not, (t = 2.17, p <0.031). (d) Employees who were involved in office accidents rated higher the questions of the factor health and safety issues in the office (t = -2.52, p <0. 015) and lower the factor workplace environmental conditions (t = -2.07, p = .043). It is concluded that despite the differences in the rating health and safety scale, in relation to selected variables, perceptions of employees regarding the management health and safety in the office work are positive.