Health and wellbeing spillovers of a partner's cancer diagnosis

Angelini, Viola; Costa-i-Font, Joan

doi:10.1016/j.jebo.2023.06.001

Cited by 1 publication

(1 citation statement)

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“…Our identified studies revealed three key things: (1) when indirect costs are accounted for in terms of productivity loss, premature death or informal care, they can be potentially higher than any other direct cost (e.g. diagnosis, drug, and other medical costs); (2) there is a lack of studies estimating indirect costs related to breast cancer published since 2017 that have used data post-2012 in our eligible countries; and (3) studies do not often capture spill-over effects such as the impact on informal caregivers (e.g., physical/mental health and well-being burdens) alongside additional indirect out-of-pocket payments (e.g., childcare expenses), which are potentially substantial [ 75 ]. Given the potential magnitude of indirect costs, larger scale, up-to-date studies are required.…”

Section: Discussionmentioning

confidence: 99%

Direct and Indirect Costs of Breast Cancer and Associated Implications: A Systematic Review

Franklin,

Pollard,

Sah

et al. 2024

Adv Ther

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Introduction Breast cancer is currently the leading cause of global cancer incidence. Breast cancer has negative consequences for society and economies internationally due to the high burden of disease which includes adverse epidemiological and economic implications. Our aim is to systematically review the estimated economic burden of breast cancer in the United States (US), Canada, Australia, and Western Europe (United Kingdom, France, Germany, Spain, Italy, Norway, Sweden, Denmark, Netherlands, and Switzerland), with an objective of discussing the policy and practice implications of our results. Methods We included English-language published studies with cost as a focal point using a primary data source to inform resource usage of women with breast cancer. We focussed on studies published since 2017, but with reported costs since 2012. A systematic search conducted on 25 January 2023 identified studies relating to the economic burden of breast cancer in the countries of interest. MEDLINE, Embase, and EconLit databases were searched via Ovid. Study quality was assessed based on three aspects: (1) validity of cost findings; (2) completeness of direct cost findings; and (3) completeness of indirect cost findings. We grouped costs based on country, cancer stage (early compared to metastatic), and four resource categories: healthcare/medical, pharmaceutical drugs, diagnosis, and indirect costs. Costs were standardized to the year 2022 in US (US$2022) and International (Int$2022) dollars. Results Fifty-three studies were included. Studies in the US ( n = 19) and Canada ( n = 9) were the majority (53%), followed by Western European countries (42%). Healthcare/medical costs were the focus for the majority (89%), followed by pharmaceutical drugs (25%), then diagnosis (17%) and indirect (17%) costs. Thirty-six (68%) included early-stage cancer costs, 17 (32%) included metastatic cancer costs, with 23% reporting costs across these cancer stages. No identified study explicitly compared costs across countries. Across cost categories, cost ranges tended to be higher in the US than any other country. Metastatic breast cancer was associated with higher costs than earlier-stage cancer. When indirect costs were accounted for, particularly in terms of productivity loss, they tended to be higher than any other estimated direct cost (e.g., diagnosis, drug, and other medical costs). Conclusion There was substantial heterogeneity both within and across countries for the identified studies’ designs and estimated costs. Despite this, current empirical literature suggests that costs associated with early initiation of treatment could be offset against potentially avoiding or reducing the overall economic burden of later-stage and more severe breast cancer. Larger scale, national, economic burden studies are needed, to be updated regularly to ensure there is an ongoing and evolving...

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Section: Discussionmentioning

confidence: 99%