Increasing requirements for reliability of modern powertrainscan be achieved by predictive maintenance and reliabilitybasedcontrol based on lifetime prediction. This contributionpresents lifetime prediction for a dry clutch, being an essentialcomponent of automated manual transmissions. Modelbaseddevelopment of lifetime prediction requires knowledgeof dry clutch wear, which was identified in previous experiments.The derived wear model allows estimation of characteristicwear-dependent values, like friction lining materiallosses and friction coefficient changes. Based on these estimatedvalues the presented lifetime prediction was developedby fusing these estimated values into a health index (HI) describingthe systems healthiness. Furthermore, the remaininguseful lifetime (RUL) becomes predictable from observationsof health index trend using an exponential weightedmoving average. Eventually, the presented lifetime predictionwas implemented and tested on real-time operating hardwaresimilar to common transmission control units. In order tocontrol the system lifetime in normal operation, target trendsfor health index and predicted remaining useful lifetime weredefined. Based on trend deviations, a fuzzy-logic based controlstrategy was realized, which sets the optimization targetfor a reliability-based control. Thus, the optimization targetcan be varied between comfort-optimized or wear-optimizedclutch engagements. Finally, an outline of reliability-basedcontrol concepts is given.