Health Benefits of Key Constituents in Cichorium intybus L.

Birsa, M. L.; Sarbu, Laura Gabriela

doi:10.3390/nu15061322

Cited by 14 publications

(9 citation statements)

References 118 publications

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“…[27] Furthermore, it was postulated that α-LA could play a pivotal role in improving the concurrent challenges of diabetes-associated nephropathy and hyperglycemia in STZ-induced diabetic rats. [28] Our findings are in alignment with contemporary research highlighting the antioxidant capabilities of bioactive plant components and their potential to alleviate oxidative stress stemming from hyperglycemia. [29] T A B L E 1 Biochemical estimations, body weight, and blood glucose in different groups.…”

Section: Discussionsupporting

confidence: 83%

Nephro‐protective effects of alpha‐lipoic acid in type I diabetes

Kushwaha,

Mandal,

Khurana

et al. 2024

J Biochem & Molecular Tox

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Type 1 diabetes (T1D) is an insulin‐dependent autoimmune condition. Short chain fatty acids (SCFAs) are volatile fatty acids with 1–6 carbon atoms that influence glucose storage in the body and can reduce appetite, potentially decreasing T1D risk. Alpha‐lipoic acid (α‐LA), a type of SCFA, has previously been used to treat diabetic neuropathy and inflammation due to its antioxidant properties. This study aims to assess α‐LA's protective effects against T1D and associated kidney damage in rats induced with streptozotocin. Diabetic rats were treated with α‐LA orally for 15 days, resulting in improved blood glucose (56% decrease) and kidney function markers like blood urea nitrogen, creatinine and uric acid. α‐LA also showed significant antioxidant effects by decreasing LPO as well as improving activities of antioxidant enzymes like superoxide dismutase, catalase and glutathione‐S transferase and alleviated kidney damage caused by diabetes. Docking experiments suggest that α‐LA may regulate diabetes‐related changes at the epigenetic level through interactions with the SIRT1 protein, indicating its potential as a target for future antidiabetic drug development.

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Section: Discussionsupporting

confidence: 83%

Nephro‐protective effects of alpha‐lipoic acid in type I diabetes

Kushwaha,

Mandal,

Khurana

et al. 2024

J Biochem & Molecular Tox

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“…The present study showed that CA also alleviated Aβ pathology and improved the expression of synaptic-function-related markers via L1. It is noted that some active substances in traditional Chinese herbs, such as chlorogenic acid and ursolic acid, have similar roles to CA in the treatment of neurodegenerative disease [ 32 , 33 ]. Chlorogenic acid improved mitochondrial dysfunction and protected against neuronal cell death in a PD mouse model [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer’s Disease Models

Wang,

Kang,

Zhao

et al. 2024

IJMS

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Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease. The accumulation of amyloid-beta (Aβ) plaques is a distinctive pathological feature of AD patients. The aims of this study were to evaluate the therapeutic effect of chicoric acid (CA) on AD models and to explore its underlying mechanisms. APPswe/Ind SH-SY5Y cells and 5xFAD mice were treated with CA. Soluble Aβ1–42 and Aβ plaque levels were analyzed by ELISA and immunohistochemistry, respectively. Transcriptome sequencing was used to compare the changes in hippocampal gene expression profiles among the 5xFAD mouse groups. The specific gene expression levels were quantified by qRT-PCR and Western blot analysis. It was found that CA treatment reduced the Aβ1–42 levels in the APPswe/Ind cells and 5xFAD mice. It also reduced the Aβ plaque levels as well as the APP and BACE1 levels. Transcriptome analysis showed that CA affected the synaptic-plasticity-related genes in the 5xFAD mice. The levels of L1CAM, PSD-95 and synaptophysin were increased in the APPswe/Ind SH-SY5Y cells and 5xFAD mice treated with CA, which could be inhibited by administering siRNA-L1CAM to the CA-treated APPswe/Ind SH-SY5Y cells. In summary, CA reduced Aβ levels and increased the expression levels of synaptic-function-related markers via L1CAM in AD models.

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“…The results showed that the administration of chicory could improve oxidative stress and promote the protection of chicory against atherosclerosis. 112,113…”

Section: Pharmacological Activitymentioning

confidence: 99%

Research Progress on the Homologous Effects of Cichorium glandulosum Boiss. et Huet on Medicine and Food: A Review

Yang,

Lei,

Yan

et al. 2024

Natural Product Communications

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Cichorium glandulosum Boiss. et Huet is a genus of chicory in the family of Asteraceae, and it is a “medicine food homology” herbal medicine, which has the effect of detoxifying heat, diuretic and swelling, and strengthening the stomach. This paper reviews the chemical composition, pharmacological effects, and practical applications of Cichorium glandulosum Boiss. et Huet and provides a comprehensive account of its role in human health and diet, pharmacological activities, and toxicity. Cichorium glandulosum Boiss. et Huet, “medicine food homology” herbal medicine, is often widely used in compound formulations with functions such as clearing the liver, promoting gallbladder, and enhancing immunity. Previous studies have found that multiple chemical components have been isolated and identified from Cichorium glandulosum Boiss. et Huet, mainly including 89 compounds such as flavonoids, terpenoids, phenolic acids, polysaccharides, and phenylpropanoids. Meanwhile, the extract has various biological activities, including hepatoprotective and hypoglycemic, regulating blood lipids, aiding digestion, anticancer, regulating intestinal microbiota and immune function, antioxidant, and has been proven in both in vivo and in vitro studies. As an important plant resource, the current research focuses on the traditional efficacy of Cichorium glandulosum Boiss. et Huet. The chemical composition of this genus of plants is complex and their pharmacological activities are diverse. Further in-depth studies on the molecular mechanisms and toxic side effects of its specific compounds in the organism are needed. Therefore, this review provides a reference for the development and utilization of Cichorium glandulosum Boiss. et Huet.

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Health Benefits of Key Constituents in Cichorium intybus L.

Cited by 14 publications

References 118 publications

Nephro‐protective effects of alpha‐lipoic acid in type I diabetes

Nephro‐protective effects of alpha‐lipoic acid in type I diabetes

Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer’s Disease Models

Research Progress on the Homologous Effects of Cichorium glandulosum Boiss. et Huet on Medicine and Food: A Review

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