Health benefits of Mediterranean diet in nonalcoholic fatty liver disease

Abenavoli, Ludovico; Renzo, Laura Di; Boccuto, Luigi; Alwardat, Nuha; Gratteri, Santo; Lorenzo, Antonino De

doi:10.1080/17474124.2018.1503947

Cited by 54 publications

(33 citation statements)

References 76 publications

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“…The etiology of the disease is multifactorial, and its onset and progression depend on factors related to diet, weight, gut microbiota, in addition to the contribution of genetic factors [4][5][6]. The presence of the disease is correlated with obesity and is present in up to 91% of severely obese patients (Body mass index-BMI > 35 kg/m 2 ) [7].…”

Section: Introductionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in C57bl/6 Models

et al. 2019

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Researchers have a range of animal models in which to study Nonalcoholic fatty liver disease (NAFLD). Induction of NAFLD by a high-fat diet in the C57BL/6 strain is the most widely used among mice. In this study, we review works that performed NAFLD induction by a high-fat diet using the C57BL/6 strain, focusing on experiments on the effects of lipid ingestion. Studies are initially distinguished into researches in which mice received lipids by oral gavage and studies in which lipid was added to the diet, and each of these designs has peculiarities that must be considered. Oral gavage can be stressful for animals and needs trained handlers but allows accurate control of the dose administered. The addition of oils to the diet can prevent stress caused to mice by gavage, but possible changes in the consistency, taste, and smell of the diet should be considered. Regarding the experimental design, some variables, such as animal sex, treatment time, and diet-related variables, appear to have a definite pattern. However, no pattern was found regarding the number of animals per group, age at the beginning of the experiment, time of adaptation, the substance used as a vehicle, and substance used as a control.

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Section: Introductionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in C57bl/6 Models

et al. 2019

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“…The Western dietary pattern characterised by higher loads of energy content, saturated fat, fructose, sugar-sweetened beverages and refined carbohydrates is associated with weight gain, obesity and more recently with NAFLD (6) . Although there is currently no consensus on the pharmacological treatment of NAFLD, the international guidelines recommend that lifestyle modification associated with weight loss should be an integral part of the treatment of NAFLD (7) .…”

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confidence: 99%

Food groups and the likelihood of non-alcoholic fatty liver disease: a systematic review and meta-analysis

Guo

et al. 2020

Br J Nutr

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“…During the recruitment visit, all subjects received appropriate recommendations about dietary and physical activity lifestyle, according to each site protocols. Recommendations mainly focused on physical activity and healthy diet (15) , in particular through adhesion to Mediterranean diet (16) .…”

Section: Interventionsmentioning

confidence: 99%

Randomised trial of chronic supplementation with a nutraceutical mixture in subjects with non-alcoholic fatty liver disease

et al. 2019

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A mixture of natural ingredients, namely, DHA, phosphatidylcholine, silymarin, choline, curcumin and d-α-tocopherol, was studied in subjects with non-alcoholic fatty liver disease (NAFLD). Primary endpoints were serum levels of hepatic enzymes, and other parameters of liver function, the metabolic syndrome and inflammation were the secondary endpoints. The coagulation–fibrinolysis balance was also thoroughly investigated, as NAFLD is associated with haemostatic alterations, which might contribute to increased cardiovascular risk of this condition. The present study involved a double-blind, randomised, multicentre controlled trial of two parallel groups. Subjects with NAFLD (18–80 years, either sex) received the active or control treatment for 3 months. All assays were performed on a total of 113 subjects before and at the end of supplementation. The hepatic enzymes aspartate aminotransferase (AST), alanine aminotransferase and γ-glutamyl transpeptidase decreased from 23·2 to 3·7 % after treatment, only the AST levels reaching statistical significance. However, no differences were found between control and active groups. Metabolic and inflammatory variables were unchanged, except for a slight (less than 10 %) increase in cholesterol and glucose levels after the active treatment. Coagulation–fibrinolytic parameters were unaffected by either treatment. In conclusion, chronic supplementation with the mixture of dietary compounds was well tolerated and apparently safe in NAFLD subjects. The trial failed to demonstrate any efficacy on relevant physiopathological markers, but its protocol and results may be useful to design future studies with natural compounds.

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Health benefits of Mediterranean diet in nonalcoholic fatty liver disease

Cited by 54 publications

References 76 publications

Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in C57bl/6 Models

Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in C57bl/6 Models

Food groups and the likelihood of non-alcoholic fatty liver disease: a systematic review and meta-analysis

Randomised trial of chronic supplementation with a nutraceutical mixture in subjects with non-alcoholic fatty liver disease

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