2017
DOI: 10.1002/mnfr.201600670
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Health benefits of methylxanthines in neurodegenerative diseases

Abstract: Methylxanthines (MTXs) are consumed by almost everybody in almost every area of the world. Caffeine, theophylline and theobromine are the most well-known members of this family of compounds; they are present, inter alia, in coffee, tea, cacao, yerba mate and cola drinks. MTXs are readily absorbed in the gastrointestinal tract and are able to penetrate into the central nervous system, where they exert significant psychostimulant actions, which are more evident in acute intake. Coffee has been paradigmatic, as i… Show more

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Cited by 81 publications
(59 citation statements)
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References 140 publications
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“…In humans, the plasma concentration of theobromine has been reported to be as high as 63 µM following the consumption of chocolate (Oñatibia‐Astibia et al, ). The relationship between Ki and inhibitor concentration for a noncompetitive inhibitor is given by equation 1:Vmaxapp=Vmax1+IKi…”
Section: Discussionmentioning
confidence: 99%
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“…In humans, the plasma concentration of theobromine has been reported to be as high as 63 µM following the consumption of chocolate (Oñatibia‐Astibia et al, ). The relationship between Ki and inhibitor concentration for a noncompetitive inhibitor is given by equation 1:Vmaxapp=Vmax1+IKi…”
Section: Discussionmentioning
confidence: 99%
“…The longer half-life of theobromine may mean its effects will be more prolonged than those of caffeine. It is also important to note that theobromine may be formed from caffeine breakdown in vivo (Oñatibia-Astibia, Franco, & Martínez-Pinilla, 2017).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…One of the hypothesis behind the benefits of sustained methylxanthine intake for the CNS, also backed up by the fact that virtually all societies have methylxanthinecontaining beverages, is that active neurons are less prone to death. Adenosine receptor antagonism produces neuronal activation and, eventually, active neurons have more tools to cope with environmental factors leading to oxidative stress (Franco et al, 2013;Oñatibia-Astibia et al, 2017).…”
Section: Caffeine and Other Methylxanthinesmentioning
confidence: 99%
“…stimulation of the central nervous system and gastric secretion, diuresis, bronchodilation, and stimulation of skeletal muscles in high doses . They also display health benefits in diseases involving cell death in the nervous system (Oñatibia Astibia, Franco, & Martínez Pinilla, 2017).…”
Section: Introductionmentioning
confidence: 99%