Health benefits of xylitol

Benahmed, Asma Gasmi; Gasmi, Amin; Arshad, Maria; Shanaida, Mariia; Lysiuk, Roman; Peana, Massimiliano; Pshyk‐Titko, Irena; Adamiv, Stepan; Shanaida, Yurii; Bjørklund, Geir

doi:10.1007/s00253-020-10708-7

Cited by 102 publications

(54 citation statements)

References 93 publications

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“…It has applications in dental and oral diseases. Due to its excellent anti-inflammatory potential, xylitol can be used to cure chronic inflammatory diseases effectively (Benahmed et al, 2020). It is also used to treat the respiratory diseases such as pneumonia and middle ear infections.…”

Section: Xylitolmentioning

confidence: 99%

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Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica

Abbasi

Liu

Zhi

et al. 2021

Front. Bioeng. Biotechnol.

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The sugar alcohols and functional sugars have wide applications in food, pharmaceutical, and chemical industries. However, the smaller quantities of natural occurring sugar alcohols and functional sugars restricted their applications. The enzymatic and whole-cell catalyst production is emerging as the predominant alternatives. The properties of Yarrowia lipolytica make it a promising sugar alcohol and functional sugar producer. However, there are still some issues to be resolved. As there exist reviews about the chemical structures, physicochemical properties, biological functions, applications, and biosynthesis of sugar alcohols and/or functional sugars in Y. lipolytica, this mini review will not only update the recent advances in enzymatic and microbial production of sugar alcohols (erythritol, D-threitol, and xylitol) and functional sugars (isomaltulose, trehalose, fructo-oligosaccharides, and galacto-oligosaccharides) by using recombinant Y. lipolytica but also focus on the studies of gene discovery, pathway engineering, expanding substrate scope, bioprocess engineering, and novel breeding methods to resolve the aforementioned issues.

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Section: Xylitolmentioning

confidence: 99%

“…In mammals, xylitol is responsible for the secretion of insulin in blood plasma. It also plays a role in the reduction of obesity and some other metabolic syndromes (Benahmed et al, 2020). In addition, it is also used in sugar free gum and is commonly not harmful to humans but can be highly toxic to dogs (Rajapaksha et al, 2019).…”

Section: Xylitolmentioning

confidence: 99%

Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica

Abbasi

Liu

Zhi

et al. 2021

Front. Bioeng. Biotechnol.

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“…Як можна запобігти зазначенним відхиленням? Перспективою є застосування препаратів ксилітолу, який не є інсулінозалежним джерелом енергії та може перешкоджати переходу з циклу Кребса на інші шляхи метаболізму [2].…”

Section: г і н е к о л о г і яunclassified

“…Ксилітол здатен компенсувати дефіцит НАДН у хворих на гемолітичну анемію. Також є дані, що він може знижувати проліферацію онкоклітин [2,4]. Ксилітол підсилює процеси ліполізу, сприяє редукції жирової тканини та чинить лікувальний вплив при дисліпідемії.…”

Section: г і н е к о л о г і яunclassified

“…Ксилат як інсуліннезалежне джерело енергії може перешкоджати переходу з циклу Кребса на інші шляхи метаболізму. Це може бути запорукою його використання для профілактики та лікування остеопорозу [2].…”

Section: г і н е к о л о г і яunclassified

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Possibilities of using xylitol and L-arginine drugs in menopause management

Лахно

2021

RHW

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Menopause is accompanied by the development of a complex of disorders leading to the onset of metabolic syndrome X. In the pathogenesis of these disorders, hypoestrogenemia and hyperandrogenaemia play a significant role, which cause obesity, dyslipidemia, and type 2 diabetes mellitus. Adipose tissue is a «field» for the synthesis of mediators of chronic inflammation and oxidative stress. Unfortunately, hormone replacement therapy is not recognized as an intervention for preventing metabolic disorders. Since metabolic disorders reduce the duration of the period of working capacity and life in general, it is necessary to develop a management program focused on preventing or reducing their negative impact on the woman’s well-being. Xylitol is known as an energy-balancing agent with excellent anticatabolic effects. Recently, it was found that xylitol levels can be used to predict the prospects for weight loss without surgery in morbid obesity patients. The normalization of endothelial function is one of the key tasks in the management of menopausal women. It has been proven that a decrease in the level of nitric oxide in women of transitional age causes the development of vasculopathy. Since L-arginine is a substrate for the synthesis of nitric oxide, the use of its preparations is a promising option for women receiving hormone replacement therapy. The development of a therapeutic and prophylactic strategy using hormone replacement therapy, well-balanced physical activity, diet therapy and the use of xylitol and L-arginine preparations can become a reserve for improving the quality of life of women aged over 45. Possible criteria for assessment the effectiveness of a treatment program designed for six months are blood pressure, body mass index, blood glucose, HOMA index, lipid profile, micronutritients levels, as well as an assessment on the Kuperman scale.

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From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

De Lauretis,

Øvrebø,

Romandini

et al. 2024

Advanced Science

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Periodontitis is a dysbiosis‐driven inflammatory disease affecting the tooth‐supporting tissues, characterized by their progressive resorption, which can ultimately lead to tooth loss. A step‐wise therapeutic approach is employed for periodontitis. After an initial behavioral and non‐surgical phase, intra‐bony or furcation defects may be amenable to regenerative procedures. This review discusses the regenerative technologies employed for periodontal regeneration, highlighting the current limitations and future research areas. The search, performed on the MEDLINE database, has identified the available biomaterials, including biologicals (autologous platelet concentrates, hydrogels), bone grafts (pure or putty), and membranes. Biologicals and bone grafts have been critically analyzed in terms of composition, mechanism of action, and clinical applications. Although a certain degree of periodontal regeneration is predictable in intra‐bony and class II furcation defects, complete defect closure is hardly achieved. Moreover, treating class III furcation defects remains challenging. The key properties required for functional regeneration are discussed, and none of the commercially available biomaterials possess all the ideal characteristics. Therefore, research is needed to promote the advancement of more effective and targeted regenerative therapies for periodontitis. Lastly, improving the design and reporting of clinical studies is suggested by strictly adhering to the Consolidated Standards of Reporting Trials (CONSORT) 2010 statement.

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Health benefits of xylitol

Cited by 102 publications

References 93 publications

Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica

Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica

Possibilities of using xylitol and L-arginine drugs in menopause management

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

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