PrefaceThe Agency for Healthcare Research and Quality (AHRQ), through its Evidence-based Practice Centers (EPCs), sponsors the development of evidence reports and technology assessments to assist public-and private-sector organizations in their efforts to improve the quality of health care in the United States.The reports and assessments provide organizations with comprehensive, evidence-based information on common medical conditions and new health care technologies and strategies. They also identify research gaps in the selected scientific area, identify methodological and scientific weaknesses, suggest research needs, and move the field forward through an unbiased, evidence-based assessment of the available literature. The EPCs systematically review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses when appropriate prior to developing their reports and assessments.To improve the scientific rigor of these evidence reports, AHRQ supports empiric research by the EPCs to help understand or improve complex methodologic issues in systematic reviews. These methods research projects are intended to contribute to the research base in and be used to improve the science of systematic reviews. They are not intended to be guidance to the EPC program, although they may be considered by EPCs along with other scientific research when determining EPC program methods guidance.AHRQ expects that the EPC evidence reports and technology assessments, when appropriate, will inform individual health plans, providers, and purchasers as well as the health care system as a whole by providing important information to help improve health care quality.If Background. According to the Health and Medicine Division of the National Academies of Sciences, Engineering, and Medicine, in order for health care systems to improve health quality, outcomes, cost, and equity there needs to be a process for transmitting new knowledge into everyday care. Systematic reviews are one potential source of knowledge. However, little is known about the types of evidence used by health-systems and how evidence reports produced by the Agency for Healthcare Research and Quality (AHRQ) Evidence-based Practice Center (EPC) program could be used by learning health-systems.Purpose. To better understand how health-systems identify and use evidence and how EPC reports could help them with their decisionmaking in the future.Methods. From February to September 2017, an AHRQ/EPC Methods Workgroup interviewed nine individuals with leadership roles in enhancing health-system quality, safety, and process improvement from academic, non-academic, and small community health-systems, as well as health-system collaborative organizations. Workgroup members reviewed interview notes and transcripts to identify key themes and exemplar quotations. The nine Key Informants (KI) reviewed the draft report for accuracy.Results. Health-systems have various internal processes for getting and using evidence in their decisionmaking. All of the ...