29Background: The iDSI reference case, originally published in 2014, aims to improve the quality 30 and comparability of cost-effectiveness analyses (CEAs). This study assesses whether the 31 development of the guideline has improved the reporting and methodology for CEAs using 32 disability-adjusted life-years (DALYs). 33 Methods: We analyzed the Tufts Medical Center Global Health CEA Registry to identify cost-34 per-DALY averted studies published from 2011 to 2017. Among each of 11 principles in the 35iDSI reference case, we translated all reporting standards and methodological specifications into 36 quantifiable yes/no questions and awarded articles one point for each item satisfied. We then 37 separately calculated reporting and methods scores, measured as percent adherence (0%=no 38 adherence, 100%=full adherence). Using the year 2014 as the dissemination period, we 39 conducted a pre-post analysis. Additionally, we conducted an analysis stratified by the 11 40 principles and examined different scoring strategies and dissemination periods in sensitivity 41 analyses.
42Results: Articles averaged 74% adherence to reporting standards and 60% adherence to 43 methodological specifications. Adherence to reporting standards increased slightly over time 44 (72% pre-2014 vs. 75% post-2014, p<0.01), but methodological adherence did not significantly 45 improve (59% pre-2014 vs. 60% post-2014, p=0.53). Overall, reporting adherence scores 46 exceeded methodology adherence scores (74% vs. 60%, p<0.001). Articles seldom addressed 47 budget impact (9% reporting, 10% methodology) or equity (7% reporting, 7% methodology). 10/1/2018 3 48
Conclusions:The iDSI reference case has substantial potential to serve as a useful resource for 49 researchers and policy-makers in global health settings, but greater effort to promote adherence 50 and awareness is needed to achieve its potential. 10/1/2018 4 51 Background 52 Since the original Panel on Cost-Effectiveness in Health and Medicine proposed the use 53 of a reference case as a benchmark of quality and methodological rigor (1, 2), various guidelines 54 for conducting economic analyses have been proposed (3, 4). Over the last two decades, many 55 countries, particularly high-income ones, have developed their own reference cases to inform 56 decision-making in their health care systems (5-8). In contrast, most low-and middle-income 57 countries (LMICs) have not developed such guidelines, possibly due to their limited capacity to 58 do so (9).Case (10, 11) to convey the breadth of its intended applicability. The iDSI Reference Case fills a 65 major gap in global health economics, as it serves as the only resource of best practices for 66 economic evaluation for many LMICs looking for guidance on resource prioritization. To date, 67 however, no study has examined the extent to which economic evaluations adhere to the iDSI 68 guidelines. We aimed to evaluate whether the development of the iDSI reference case has 69 improved adherence to best practices for economic evaluations in glo...