OBJECTIVES: To describe the epidemiology and factors associated with pediatric central nervous system (CNS) tuberculosis (TB) in California from 1993 to 2011.
METHODS:We analyzed California TB registry data for persons aged #18 years, comparing CNS TB cases versus non-CNS TB cases reported from 1993 to 2011. Factors associated with CNS TB and TB deaths were identified by using multivariate logistic regression.RESULTS: A total of 200 CNS TB cases were reported. Compared with non-CNS TB case patients, CNS TB case patients were more likely to be aged ,5 years (72.0% vs 43.6%; odds ratio [OR] CONCLUSIONS: Subsets of children are at increased risk for CNS TB in California and may benefit from additional prevention efforts.
WHAT'S KNOWN ON THIS SUBJECT:Central nervous system (CNS) tuberculosis has high morbidity and mortality, and it frequently affects children aged ,5 years.
WHAT THIS STUDY ADDS:In California, children who were US-born, Hispanic, and aged ,5 years were at increased risk of CNS tuberculosis. Children with CNS tuberculosis were more likely to die. Specific populations of US-born infants might benefit from additional prevention measures. Dr Duque-Silva was involved in research design, performed the data analysis and interpretation, and drafted and revised the manuscript; Ms Robsky was involved in research design and assisted with data analysis and interpretation; and Dr Flood assisted in research design and data interpretation, and reviewed and revised the manuscript. Dr Barry conceptualized the study; supervised the research design, data analysis, and interpretation; and critically reviewed and revised the manuscript. All authors approved the final manuscript as submitted. 2,3 It is most commonly diagnosed in children aged ,5 years and may affect the same groups at high risk for pediatric TB in the United States such as immigrants, racial and ethnic minorities, and children who traveled to a country with high prevalence of TB or who had contact with a household visitor from a high-prevalence country. [4][5][6] In children, CNS TB is often the result of recently acquired infection after close contact with an infectious TB case in an adult. Risk of dissemination to the CNS after TB exposure is influenced by age and immune status, 7 including BCG vaccination. In most countries outside the United States, BCG vaccination is recommended in early childhood to decrease the risk of disseminated forms of TB such as miliary and CNS TB in children. 8 BCG vaccination has not routinely been used in the United States. 9 California is the state that reports the most pediatric TB cases 10 and has the largest foreign-born population in the United States. 11 It is therefore an excellent population in which to examine the epidemiology of pediatric CNS TB. To inform ongoing CNS TB prevention activities, our goal was to describe the epidemiology of pediatric CNS TB in California from 1993 to 2011 and to identify factors associated with the development of pediatric CNS TB as well as factors associated with pedia...