Health complaints and annoyances after moving into a new office building: A multidisciplinary approach including analysis of questionnaires, air and house dust samples

Hutter, Hans-Peter; Moshammer, Hanns; Wallner, Peter; Damberger, Bernhard; Tappler, Peter; Kundi, Michael

doi:10.1016/j.ijheh.2005.08.010

Cited by 46 publications

(34 citation statements)

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“…In the present study, the total number of trials of limonene detection that achieved the learning criterion in TOD was 68.3 (7-9 trials/session). The ability of odor detection in mice shown in the present study is comparable to the results of other studies that evaluated olfactory learning (Huttera et al, 2006). I concluded that TOD using mice might be one of useful 64.5 ± 2.5 * means < 0.05 (vs. SOD), a means < 0.05 (vs. no odor), b means < 0.05 (vs. cheese), c means < 0.05 (vs. limonene) in the same procedure.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of the ability of mice to detect VOCs, using a positive operant reinforcement procedure

Hojo

2015

J. Toxicol. Sci.

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-To examine the validity of a newly established "three-odor detection (TOD)" procedure using one of volatile organic compounds (VOCs), limonene, food-restricted male mice were used. Five animals each were assigned to either TOD or single-odor detection (SOD). TOD was composed of two trainings and one test (TEST) session. Mice were trained to discriminate an odor of coffee from no odor and odors of coffee and cheese from no odor in trainings 1 and 2, respectively. In TEST, mice were required to discriminate odors of coffee, cheese, and limonene from no odor. In SOD, mice were required to discriminate an odor of limonene from no odor. Each training or test was conducted once a day until animals achieved a learning criterion (75% correct response rate for 2 consecutive days), or until a maximum number of sessions (20 sessions) was completed. The number of sessions for reaching the learning criterion of animals in TEST (8.2 ± 0.8) was smaller than that of animals in SOD (19.2 ± 0.8). Results indicated that mice in TOD detected low levels of VOCs more rapidly than animals in SOD. I concluded that TOD is a useful procedure for detecting low levels of VOCs.

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Section: Discussionsupporting

confidence: 90%

Evaluation of the ability of mice to detect VOCs, using a positive operant reinforcement procedure

Hojo

2015

J. Toxicol. Sci.

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“…Because of its ubiquity, DEHP appears in almost every house dust sample. Dust samples collected in office buildings in Austria showed DEHP concentrations ranging up to 3 mg/g (Hutter et al 2006). The median concentration of DEHP in dust collected in children’s bedrooms in 346 homes in Sweden was 0.7 mg/g (Bornehag et al 2004).…”

Section: Discussionmentioning

confidence: 99%

A Controlled Challenge Study on Di(2-ethylhexyl) Phthalate (DEHP) in House Dust and the Immune Response in Human Nasal Mucosa of Allergic Subjects

Deutschle

Reiter

Butte

et al. 2008

Environ Health Perspect

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BackgroundFew studies have yet addressed the effects of di(2-ethylhexyl) phthalate (DEHP) in house dust on human nasal mucosa.ObjectivesWe investigated the effects of house dust containing DEHP on nasal mucosa of healthy and house dust mite (HDM)–allergic subjects in a short-term exposure setting.MethodsWe challenged 16 healthy and 16 HDM-allergic subjects for 3 hr with house dust at a concentration of 300 μg/m3 containing either low (0.41 mg/g) or high (2.09 mg/g) levels of DEHP. Exposure to filtered air served as control. After exposure, we measured proteins and performed a DNA microarray analysis.ResultsNasal exposure to house dust with low or high DEHP had no effect on symptom scores. Healthy subjects had almost no response to inhaled dust, but HDM-allergic subjects showed varied responses: DEHPlow house dust increased eosinophil cationic protein, granulocyte-colony–stimulating factor (G-CSF), interleukin (IL)-5, and IL-6, whereas DEHPhigh house dust decreased G-CSF and IL-6. Furthermore, in healthy subjects, DEHP concentration resulted in 10 differentially expressed genes, whereas 16 genes were differentially expressed in HDM-allergic subjects, among them anti-Müllerian hormone, which was significantly up-regulated after exposure to DEHPhigh house dust compared with exposure to DEHPlow house dust, and fibroblast growth factor 9, IL-6, and transforming growth factor-β1, which were down-regulated.ConclusionsShort-term exposure to house dust with high concentrations of DEHP has attenuating effects on human nasal immune response in HDM-allergic subjects, concerning both gene expression and cytokines.

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“…B. eine Vergiftung bezüglich des Auftretens unspezifischer Beschwerden bei den Betroffenen [1, 6,8] oder beschrieben unspezifische Beschwerden bei Patienten, die ihren Arzt im Rahmen einer Partnerschaftsproblematik aufsuchten [10].…”

Section: Introductionunclassified

Unspezifische Beschwerden als Beratungsergebnis in einer Allgemeinarztpraxis

Schäfer

Apel²,

Zilian³

et al. 2006

Z Allg Med

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ZusammenfassungHintergrund: Beratungsergebnisse lassen sich im derzeitigen Abrechnungssystem nicht valide mittels der Routine-Daten erfassen, da die "Krankenscheindiagnosen" Abrechnungsbegrün-dungen darstellen, aber nicht das tatsächliche Geschehen in der Hausarztpraxis abbilden. Methoden: Im Rahmen einer Praxisstudie einer großen ländlichen Allgemeinarztpraxis wird der Anteil unspezifischer Beschwerden an der Gesamtzahl der Beratungsergebnisse des Jahres 2005 (n = 12 861) ermittelt. Ergebnisse: Unspezifische Beschwerden als Beratungsergebnis sind mit 6,6 % relativ gering aber regelmäßig anzutreffen. Durch gezieltes Befragen lassen sich 70 % dieser Beschwerden individuellen oder sozialen Problemen der Patienten zuordnen. Schlussfolgerung: Beratungsergebnisse, die sich nicht primär einem Fachgebiet zuordnen lassen, sind in unserer Praxis selten und dann meistens durch psychosoziale Belastungen erklärbar. Für die restlichen 2 % der Beratungsergebnisse empfiehlt sich eine programmierte/strukturierte Diagnostik, um abwendbar gefähr-liche Verläufe zu erkennen. SchlüsselwörterUnspezifische Beschwerden · Fälle-Verteilung · Differenzierung · programmierte Diagnostik · psychosoziale Probleme Abstract Background: Results of consultation cannot be easily obtained in General Practice in Germany, because routine data do not reflect the real situation in practice -they are used as reasons for accounts. Methods: In a large rural general practice, the total number of consulting conclusions of the year 2005 (n = 12 861) was analysed. Persons with organic symptoms, which could be assigned to special clinical pictures are compared with those having only unspecific symptoms. Results: Within the relatively low percentage of persons with unspecific symptoms (6.6 %) most patients had psychosocial problems (70 %). Conclusion: About 2 % of the consultations could not be analysed by common methods and should be examined by programmed or structured diagnosis in order to explore the cause of their complaints and to avert a dangerous development

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Health complaints and annoyances after moving into a new office building: A multidisciplinary approach including analysis of questionnaires, air and house dust samples

Cited by 46 publications

References 3 publications

Evaluation of the ability of mice to detect VOCs, using a positive operant reinforcement procedure

Evaluation of the ability of mice to detect VOCs, using a positive operant reinforcement procedure

A Controlled Challenge Study on Di(2-ethylhexyl) Phthalate (DEHP) in House Dust and the Immune Response in Human Nasal Mucosa of Allergic Subjects

Unspezifische Beschwerden als Beratungsergebnis in einer Allgemeinarztpraxis

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