Rates of suicide in the United States are highest in middle-aged and older adults compared to younger age groups. These rates are alarming and point to the need for suicide prevention research in middle-aged and older adult populations. Depression is the most well-established independent risk factor for death by suicide. Some health conditions are also associated with risk of suicide above and beyond depression. Diabetes is often co-morbid with depression (clinical and subclinical depression). However, research examining diabetes and risk of suicide is less clear. In the current study, the first aim was to examine diabetes, vision impairment and depressive symptoms. Controlling for age, gender, marital status, weight and education, diabetes predicted depressive symptoms in a multiple linear regression. Impaired vision partially explained the association between diabetes and depressive symptoms. Additionally, marital status and gender both had an interaction effect in the relation between diabetes and depressive symptoms. The second aim examined diabetes and risk of suicide; however, due to low power, the findings could not be interpreted. Future studies should examine diabetes and risk of suicide with a larger U.S. sample of middle-aged and older adults. The diabetes-depressive symptoms findings are important when considering practice and policy related to mental health in middleaged and older adult populations who are diagnosed with diabetes. Examining Diabetes, Depression and Suicide in Middle-Aged and Older Adults Centers for Disease Control and Prevention (CDC) data indicate that there is a spike in rate of suicide during middle-age as well as in the oldest old, i.e., individuals > age 85; therefore, research in this area is imperative to continue to identify risk factors that contribute to suicide in middle-age and older adult populations. The rate of suicide is 12.7 per 100,000 people in the United States; however, the rate for individuals 65 and older is 15.3 per 100,000 people in the U.S., and, for individuals age 85+, the rate increases to 16.9 per 100,000 in the U.S. (Health Status and Determinants, 2013). Sweden's rate of suicide in middle-aged and older adults per 100,000 people is similar to rates in the U.S.: 45-54 years, 19.0; 55-64 years, 17.9; 65-74 years, 16.7; and 75+, 16.9. In 2013, after examining suicide rates for 1999-2010 in the U.S., the CDC reported that rate of suicide among middle-aged adults (i.e., 35 to 64) increased by 28%. Moreover, because non-violent suicide deaths in older adults can mistakenly be classified as accidental overdoses of prescription drugs or attributed to medical conditions, reported statistics may actually be underestimating death by suicide in the older adult population (Batty, Kivimaki, Park, & Jee, 2012). These statistics are alarming and point to the need for suicide prevention research in middle-aged and older adult populations. This paper focused on two possible risk factors: diabetes and depression. Throughout this paper, the terms depression, major depres...