“…Briefly, several authors reported that differences in the HRs are explained by the vast heterogeneity in the baselines due to the inclusion of ulcers with different sizes and of different duration [18, 19]. Our results confirm the above reports and show that the inclusion of ulcers of different sizes (large and short) and ulcers of different durations (short and long) contribute to severe heterogeneity in the baselines and differences in the HR among the reviewed bandages of four-LB, SSB compression, two-L SSB, four-L LSB, two-L LSB, and KTwo [12, 24, 27-30, 32, 34, 35, 42-44]. Again, this heterogeneity is still a significant limitation in the design of the current research, which needs to be addressed in future clinical studies.…”