The relationship between air pollution and public health has gained increasing attention in the past decade. Many time-series analyses have been conducted worldwide, including in all the major cities of the United States, Europe, and Asia. However, the most current timeseries analysis study of Ontario, Canada dates back to 2012 and includes only a single city, calling the need of a more recent study at a provincial scale. As a result, we propose to The relationship between air pollution and public health has gained increasing attention in the past decade. Many time-series analyses have been conducted worldwide, including all the major cities in the United States, Europe, and Asia. However, the most current time-series analysis study of Ontario, Canada dates back to 2012 and is included only a single city, calling the need of a more recent study at a provincial scale. As a result, we propose to conduct time-series analyses of major Ontario cities and then use a hierarchical model to pool the results and construct a dose-response relationship and generate a predictive regression. Correspondence: zengy10@mcmaster.ca