Health effects in children aged 3–6 years induced by environmental lead exposure

Jin, Yaping; Liao, Yingjun; Lu, Chun-Wei; Li, Gexin; Yu, Fei; Zhi, Xu; Xu, Jianhong; Liu, Shaoxia; Liu, Meimei; Yang, Jun

doi:10.1016/j.ecoenv.2005.05.011

Cited by 44 publications

(35 citation statements)

References 15 publications

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“…Studies of children from India and China have reported the significant decreases in ALAD activity are associated with BLLs C10 lg/dl. Further the inverse correlations between BLL and ALAD activity were found in mothers (at delivery) and their newborns (cord blood) [32].…”

Section: Discussionmentioning

confidence: 92%

Impact of Chronic Lead Exposure on Selected Biological Markers

et al. 2011

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Lead poisoning remains a major problem in India due to the lack of awareness of its ill effects among the clinical community. Blood lead, d-aminolevulinic acid dehydratase (d-ALAD) and zinc protoporphyrin (ZPP) concentrations are widely used as biomarkers for lead toxicity The present study was designed to determine the impact of chronic lead exposure on selected biological markers. A total of 250 subjects, of both sexes, ranging in age from 20 to 70 years, were recruited. On the basis of BLLs, the subjects were categorized into four groups: Group A (BLL: 0-10 lg/dl), Group B (BLL: 10-20 lg/dl). Group C (BLL: 20-30 lg/dl) and Group D (BLL: 30-40 lg/dl) having BLLs of 3.60 ± 2.71 lg/dl, 15.21 ± 2.65 lg/dl, 26.82 ± 2.53 lg/dl and 36.38 ± 2.83 lg/dl, respectively. Significant changes in biological markers due to elevated BLLs were noted. The relation of BLL and biological markers to demographic characteristics such as sex, habits, diet and substances abuse (smoking effect) were also studied in the present investigation. Males, urban population, non-vegetarians, and smokers had higher blood lead levels. d-ALAD activity was found to be significantly lower with increased BLL (P \ 0.001), while the ZPP level was significantly higher with increased BLL (P \ 0.001). Further, BLL showed a negative correlation with d-ALAD (r = -0.425, P \ 0.001, N = 250) and a positive correlations with ZPP (r = 0.669, P \ 0.001, N = 250). Chronic lead exposure affects the prooxidantantioxidant equilibrium leading to cellular oxidative stress.

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Section: Discussionmentioning

confidence: 92%

Impact of Chronic Lead Exposure on Selected Biological Markers

et al. 2011

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“…Lead has long been recognized as a potential hazard to human health [74,[76][77][78]. A significant ecotoxicological risk for a wild population, associated with high Pb tissues concentration has been estimated [79].…”

Section: Lead -Toxic Effects On Animals and Humansmentioning

confidence: 99%

Zeolites versus Lead Toxicity

R¹

2015

J Bioequiv Availab

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“…Children are very sensitive to Pb, for it could jeopardize their nerve and mental development (Jin et al, 2006;Sovcikova et al, 1996). Table 6 shows that the THQ c value for Pb was very close to or exceeded the level considered to be non-carcinogenic at the 99th percentile or higher.…”

Section: Health Risk From Heavy Metals In Vegetablesmentioning

confidence: 99%