Health effects of ethanolic extract from seeds of lady finger

Abstract

Health benefits of lady finger were explored in this study by which the ethanol extract from the seeds was utilized for testing. In high glucose (350 mmole/L) medium, the proliferative activity of C2C12 cells was inferior, but their viability was improved following treated with the extract. The activities of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT), were also enhanced. In response to such high glucose concentration, glucose uptake ability of these cells was compromised. The extract was demonstrated to increase the ability of glucose uptake by approximately equal to the effect of 200 nmole/L insulin. High intracellular reactive oxygen species (ROS) of RBM-MCS cells grown in high glucose containing medium was elicited. The level of ROS was reduced when the cells were cultured in contact with the extract. L929 cells were made inflammation and oxidative stress by incubating with 37.5 µmole/L DPPH for 30 min. The release of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) from these inflamed cells was inhibited by such treatment. Thus, lady finger might be advantageous in the protection of cells in the body that would be damaged or being susceptible to hyperglycemia and diabetes.

Effects of okra (Abelmoschus esculentusL) on inflammatory mediators: a systematic review of preclinical studies

“…Gou et al 22 also showed that 150 μg mL −1 okra inhibited the IL-6 mRNA expression in high fat induced-human aortic endothelial cells. Kaewsrichan et al 20 indicated that 1.25 and 2.5 mg mL −1 okra seed ethanolic extract inhibited the TNF-α and IL-6 release in the inflamed cell lines of an L929 mouse fibroblast, PC12 rat adrenal gland, and C2C12 mouse myoblast. Yan et al 21 indicated that 12.5, 25, 50, and 100 μg mL −1 okra polysaccharide decreased the release and mRNA expression of IL-6 and TNF-α in LPS-stimulated BV-2 microglia cells, whereas it did not affect the IL-1β…”