Health Effects of Particulate Uranium Exposure

Zhang, Liandong; Chu, Jian; Xia, Binyuan; Xiong, Zuhong; Zhang, Shaoyu; Tang, Wei

doi:10.3390/toxics10100575

Cited by 23 publications

(5 citation statements)

References 99 publications

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“…Uranium, which is known for its extreme toxicity, radioactivity, and carcinogenic properties, can lead to numerous health problems in humans. 96 Phosphate ions are used as fertilizers, but these ions are highly toxic. 97 They are extensively used in agriculture and can be fatal when ingested at elevated quantities, whether accidently or intentionally.…”

Section: Adsorptive Pollutant Removal By Microgels (Adsorbents)mentioning

confidence: 99%

Exploring microgel adsorption: synthesis, classification, and pollutant removal dynamics

Arif

2024

RSC Adv.

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Section: Adsorptive Pollutant Removal By Microgels (Adsorbents)mentioning

confidence: 99%

Exploring microgel adsorption: synthesis, classification, and pollutant removal dynamics

Arif

2024

RSC Adv.

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“…Thus it can easily inhaled by humans and its radiotoxicity directly affect at the cellular, subcellular and protein levels, similarly it also affects kidney 151 . Human beings also exposed through environmental uranium from ingesting water or food in natural uranium-contaminated areas 152 .…”

Section: Uranium Toxicity In Humanmentioning

confidence: 99%

Uranium Sources, Uptake, Translocation in the soil-plant System and Its Toxicity in Plants and Humans: A Critical Review

et al. 2023

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Uranium(U) is one of the highly toxic heavy metals and radionuclides that has become a major threat to soil health. There are two types of sources of Uranium in the soil system, natural and anthropogenic. Natural sources of uranium include rock systems and volcanic eruptions while anthropogenic sources include mining activities, disposal of radioactive waste, application of phosphate fertilizers, etc. Uranium accumulation impacts germination, early seedling growth, photosynthesis, metabolic and physiological processes of the plants. Through its accumulation in the aerial parts of the plants, Uranium finds its way to the human body, where it has deleterious health impacts. Different studies have identified the various sources of Uranium, explored, and explained the geochemistry of Uranium in soil, assessed the Uranium uptake and toxicity to the plants, and further studied the impact on human health. Most studies focused on two stages, either soil-plant or plant-human system. However, few studies have critically reviewed and summarized the U in the soil-plant-human system. Thus, the review has been designed to focus on the sources, geochemical behaviour, uptake, and translocation, plant toxicity, food chain entry, and finally, impact on human health. The relationship between the bioavailability of Uranium in the soil-plant system with soil properties like pH, Organic matter, and microorganisms have also been included. The study is further intensified by analyzing the accumulation of Uranium in various parts of the plants.

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“…LC is more frequent in high-income countries, mainly due to smoking habits that represent the main risk factor for this malignancy ( McIntyre and Ganti, 2017 ; Sung et al, 2021 ). Other common risk factors are the exposure to some chemicals such as asbestos ( Markowitz, 2022 ), mustard gas ( Ghanei and Harandi, 2010 ), radon ( Lorenzo-González et al, 2019 ), arsenic ( Soza-Ried et al, 2019 ), chromium ( Kouokam et al, 2022 ), nickel ( Shen and Zhang, 1994 ), uranium ( Zhang et al, 2022 ), vinyl chloride ( Girardi et al, 2022 ) and high dose ionizing radiations ( Yan et al, 2022 ).…”

Section: Lung Cancer Epidemiologymentioning

confidence: 99%

Ion channels in lung cancer: biological and clinical relevance

Capitani,

Chioccioli Altadonna,

Santillo

et al. 2023

Front. Pharmacol.

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Despite improvements in treatment, lung cancer is still a major health problem worldwide. Among lung cancer subtypes, the most frequent is represented by adenocarcinoma (belonging to the Non-Small Cell Lung Cancer class) although the most challenging and harder to treat is represented by Small Cell Lung Cancer, that occurs at lower frequency but has the worst prognosis. For these reasons, the standard of care for these patients is represented by a combination of surgery, radiation therapy and chemotherapy. In this view, searching for novel biomarkers that might help both in diagnosis and therapy is mandatory. In the last 30 years it was demonstrated that different families of ion channels are overexpressed in both lung cancer cell lines and primary tumours. The altered ion channel profile may be advantageous for diagnostic and therapeutic purposes since most of them are localised on the plasma membrane thus their detection is quite easy, as well as their block with specific drugs and antibodies. This review focuses on ion channels (Potassium, Sodium, Calcium, Chloride, Anion and Nicotinic Acetylcholine receptors) in lung cancer (both Non-Small Cell Lung Cancer and Small Cell Lung Cancer) and recapitulate the up-to-date knowledge about their role and clinical relevance for a potential use in the clinical setting, for lung cancer diagnosis and therapy.

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Health Effects of Particulate Uranium Exposure

Cited by 23 publications

References 99 publications

Exploring microgel adsorption: synthesis, classification, and pollutant removal dynamics

Exploring microgel adsorption: synthesis, classification, and pollutant removal dynamics

Uranium Sources, Uptake, Translocation in the soil-plant System and Its Toxicity in Plants and Humans: A Critical Review

Ion channels in lung cancer: biological and clinical relevance

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