Health Effects of Peptides Extracted from Deer Antler

Xia, Peijun; Liu, Dongyue; Jiao, Yingying; Wang, Zhaoguo; Chen, Xi; Zheng, Shuo; Fang, Jiayuan; Hao, Linlin

doi:10.3390/nu14194183

Cited by 20 publications

(14 citation statements)

References 114 publications

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“…Many studies have shown that antlers are rich in active ingredients, which can replenish blood, invigorate energy and improve sexual function [ 6 , 7 ]. They are very rich in peptides and proteins which are considered to be important components for promoting tissue repair, antioxidant production and neuroprotection [ 8 ]. Antler polysaccharide, one of the important components of antler, is believed to prevent osteoporosis and enhance immunity [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Methionine Supplementation Affects Fecal Bacterial Community and Production Performance in Sika Deer (Cervus nippon)

Yan

Zhu

Guo

et al. 2023

Animals

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Amino acid balance is central to improving the efficiency of feed protein utilization and for reducing environmental pollution caused by intensive farming. In previous studies, supplementation with limiting amino acids has been shown to be an effective means of improving animal nutrient utilization and performance. In this experiment, the effects of methionine on the apparent digestibility of nutrients, antler nutrient composition, rumen fluid amino acid composition, fecal volatile fatty acids and intestinal bacteria in antler-growing sika deer were investigated by randomly adding different levels of methionine to the diets of three groups of four deer at 0 g/day (CON), 4 g/day (LMet) and 6 g/day (HMet). Methionine supplementation significantly increased the apparent digestibility of organic matter, neutral detergent fiber (NDF) and acid detergent fiber (ADF) in the LMet group (p < 0.05). The crude protein and collagen protein of antlers were significantly higher in the LMet and HMet groups compared to the CON group and also significantly higher in the HMet group compared to the LMet group, while the calcium content of antlers was significantly lower in the HMet group (p < 0.05). Ruminal fluid free amino acid composition was altered in the three groups of sika deer, with significant changes in aspartic acid, citrulline, valine, cysteine, methionine, histidine and proline. At the phylum level, Firmicutes and Bacteroidetes were highest in the rectal microflora. Unidentified bacterial abundance was significantly decreased in the HMet group compared to the CON group. Based on the results of principal coordinate analysis (PCoA) and Adonis analysis, there was a significant difference in the composition of the intestinal flora between the CON and HMet groups (p < 0.05). At the genus level, compared with the CON group, the abundance of Rikenellaceae_RC9_gut_group and Lachnospiraceae_UCG-010 in the LMet group increased significantly (p < 0.05), the abundance of dgA-11_gut_group in the HMet group decreased significantly (p < 0.05) and the abundance of Lachnospiraceae_UCG-010, Saccharofermentans and Lachnospiraceae_NK3A20_group increased significantly. Taken together, the results showed that methionine supplementation was beneficial in increasing the feed utilization efficiency and improving antler quality in sika deer, while affecting the composition of fecal bacteria.

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Section: Introductionmentioning

confidence: 99%

Methionine Supplementation Affects Fecal Bacterial Community and Production Performance in Sika Deer (Cervus nippon)

Yan

Zhu

Guo

et al. 2023

Animals

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“…Different studies reported certain mechanism such as the hydrolyzed deer polypeptides and polypeptides in velvet horns prevented oxidative stress and cell death by regulating the Bax/BBC-2 ratio [ 103 , 106 ]. Xia et al [ 107 ] suggested that peptides extracted from deer antler can manifest a neuroprotective ability, with a positive effect on neurological diseases through their anti-inflammatory activity and antioxidant properties. The human body is capable of producing only nine amino acids (histidine, isoleucine, leucine, lysine, methionine, threonine, tryptophan, phenylalanine, valine) of the 22 amino acids.…”

Section: Resultsmentioning

confidence: 99%

The Influence of Sensory Characteristics of Game Meat on Consumer Neuroperception: A Narrative Review

Ciobanu

Manoliu

Ciobotaru

et al. 2023

Foods

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Game meat contains bioactive compounds that directly influence the formation of a rich reservoir of flavor precursors that produce specific sensory properties. Quality is considered one of the most influential determinants of consumer behavior, but the interpretation of this concept differs between consumers. Although recognized for its quality, its unique sensory characteristics (smell, taste, aroma) may have a major impact on consumer perception. The aim of this review is to describe the consumer behavior regarding game meat through elements of neuroperception, using methods of analysis, observation, and interpretation of scientific information from the literature. Following the analysis of published papers on this topic, it was shown that external factors influencing the biological basis of behavior could provide explanations for the acceptance or rejection of this type of meat and solutions. Neuroperception can explain the mechanism behind consumer decision-making. The influence of extrinsic factors (environment, mood, emotions, stress) shapes the perception of the quality attributes of game meat, the unique sensory characteristics of game meat passing through a primary filter of sensory receptors (eyes, nose, tongue, etc). Game meat is darker and tougher (compared to meat from domestic animals), and the taste and smell have the power to trigger memories and change the mood, influencing consumer behavior. Understanding consumer attitudes towards game meat in relation to quality attributes and the physiology of sensory perception can provide important insights for food industry professionals, processors, sensory evaluators, and researchers.

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“…PAP effectively inhibits bone resorption through its antiinflammatory and antioxidative effects. PAP displays the capability to diminish bone resorption by mitigating inflammation, which accomplishes this by reducing the levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6), (44)(45)(46). By doing so, it curtails the inflammatory…”

Section: Inhibition Of Bone Resorptionmentioning

confidence: 99%

“…response, safeguarding osteoblasts, and thwarting the induction of bone resorption prompted by pro-inflammatory cytokines (44)(45)(46). Furthermore, PAP exerts an antioxidative effect that contributes to the inhibition of bone resorption.…”

Section: Inhibition Of Bone Resorptionmentioning

confidence: 99%

Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis

Wang,

Meng,

Ouyang

et al. 2023

Front. Med.

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Osteoporosis stands out as a prevalent metabolic disorder, bearing significant repercussions on human well-being and overall quality of life. It remains an urgent concern within the global public health framework due to its widespread occurrence. Osteoporosis arises from an abnormal metabolism in osteoblasts and osteoclasts, resulting in a disruption of the delicate equilibrium between bone formation and bone resorption. Within this context, deer antler peptides emerge as natural active compounds, wielding a pivotal role in governing the differentiation, proliferation, and mineralization of osteoblasts, as well as influencing the activity of osteoclasts. This article aims to consolidate our comprehension of the mechanisms underpinning the dynamic balance between bone formation and resorption, meticulously orchestrated by osteoblasts and osteoclasts in osteoporosis. Furthermore, it offers a comprehensive overview of how deer antler peptides, through their modulation of relevant signaling pathways, contribute to the enhancement of bone homeostasis. These insights deepen our understanding of the pathological processes through which deer antler peptides ameliorate bone homeostasis, while also presenting novel strategies for osteoporosis management.

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Health Effects of Peptides Extracted from Deer Antler

Cited by 20 publications

References 114 publications

Methionine Supplementation Affects Fecal Bacterial Community and Production Performance in Sika Deer (Cervus nippon)

Methionine Supplementation Affects Fecal Bacterial Community and Production Performance in Sika Deer (Cervus nippon)

The Influence of Sensory Characteristics of Game Meat on Consumer Neuroperception: A Narrative Review

Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis

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