Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review

Zúñiga-Venegas, Liliana; Hyland, Carly; Muñoz-Quezada, María Teresa; Quirós-Alcalá, Lesliam; Butinof, Maríana; Buralli, Rafael Junqueira; Fernández, Ricardo Antonio Menéndez; Foerster, Claudia; Gutiérrez-Jara, Juan Pablo; Lucero, Boris; Muñoz, Manuel J.; Ramírez-Santana, Muriel; Smith, Anna R.; Tirado, Noemí; Joode, Berna van Wendel de; Calaf, Gloria M.; Handal, Alexis J.; Silva, Agnes Soares da; Cortés, Sandra; Mora, Ana M.

doi:10.1289/ehp9934

Cited by 45 publications

(24 citation statements)

References 296 publications

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“…The results presented in this pilot study in the Maule region, Chile, showed that among the sampled population, the group of agricultural workers exhibit a high rate of genotoxic damage (MN, NPB, and NBUD frequencies) relative to their control. The results are consistent with other genotoxic studies conducted in Chile, but also from Latin American [ 45 ] and other developing countries with a similar productive model and lack of regulatory policies. For example, Kahl et al [ 46 ] evaluated genotoxic damage in 121 tobacco field workers exposed to complex pesticides mixtures in Brazil.…”

Section: Discussionsupporting

confidence: 91%

“…Among the diverse biological threats of pesticides on human health, their genotoxic potential under low-dose long-term exposures is a major risk factor for several chronic diseases [ 11 ], and it has been considered the most studied early effect biomarker [ 12 , 13 ]. Indeed, several epidemiological studies establish a direct relation between occupational exposure to pesticides and cancer [ 14 , 15 , 16 , 17 ], diabetes, respiratory, cardiovascular [ 18 , 19 ], autoimmune, and neurodegenerative diseases [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…A recent review about the health effects of pesticide exposure in Latin American and the Caribbean (LAC) populations, with a 14% of global agricultural production [ 27 ], provided some evidence that exposure to pesticides may adversely impact the health of the populations where the exposure to OP pesticides, carbamates, or to multiple pesticide classes was consistently associated with markers of genotoxicity and adverse neurobehavioral outcomes, particularly among children and farmworkers [ 13 ]. In Chile, 21% of the surface of the territory is agricultural land [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study

Landeros

Duk

Márquez

et al. 2022

IJERPH

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Significant risks to human health have been associated with chronic exposure to low doses of pesticides, a situation which may be frequent among agricultural workers. In this context, and regarding the agricultural-based economy of central Chile, we aimed to explore the genotoxic damage in agricultural workers and reproductive risk among women in rural and urban areas of Curicó, a traditional agricultural district in Chile. Hence, we sampled a group of rural agricultural workers associated with pesticide management (n = 30) and an urban unexposed group (n = 30). Our results showed that the agricultural workers had higher micronuclei frequencies (MN: β = 13.27; 95% CI low = 11.08, CI high = 15.47) and women had a 40-fold higher risk of reproductive problems (OR = 40.32; 95% CI low = 2.60, CI high = 624.31) than the unexposed group. The factor analysis of mixed data (FAMD) showed that neither the sex nor smoking habits appear to define the ordination of the data. Nevertheless, the exposure level did segregate them in the multidimensional space (explained variance: 35.38% dim-1; 18.63% dim-2). This pilot study highlights the higher risks of biological conditions negatively associated with the health of agricultural workers.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study

Landeros

Duk

Márquez

et al. 2022

IJERPH

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“…Studies have indicated that ITNs are safe to use if properly handled, and potential health risks are likely below acceptable threshold values [ 19 , 20 , 21 ]. However, it is important to be aware of possible effects that ITNs may have on people’s health since pesticides, by nature, are responsible for adverse effects such as psychomotor damage, malformations in fetuses, and cancer, among others [ 22 , 23 , 24 , 25 , 26 ]. A study stated that the insecticide permethrin , used to treat mosquito nets, was considered a neuropoison, because of its adverse effects on the nervous system, also causing itching and burning effects on exposure skin, in addition to direct inhalation [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Collateral Effects of Insecticide-Treated Nets on Human and Environmental Safety in an Epidemiological Model for Malaria with Human Risk Perception

Gutiérrez-Jara

Vogt-Geisse

Cabrera

2022

IJERPH

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Malaria remains a major health problem in many parts of the world, including Sub-Saharan Africa. Insecticide-treated nets, in combination with other control measures, have been effective in reducing malaria incidence over the past two decades. Nevertheless, there are concerns about improper handling and misuse of nets, producing possible health effects from intoxication and collateral environmental damage. The latter is caused, for instance, from artisanal fishing. We formulate a model of impulsive differential equations to describe the interplay between malaria dynamics, human intoxication, and ecosystem damage; affected by human awareness to these risks and levels of net usage. Our results show that an increase in mosquito net coverage reduces malaria prevalence and increases human intoxications. In addition, a high net coverage significantly reduces the risk perception to disease, naturally increases the awareness for intoxications from net handling, and scarcely increases the risk perception to collateral damage from net fishing. According to our model, campaigns aiming at reducing disease prevalence or intoxications are much more successful than those creating awareness to ecosystem damage. Furthermore, we can observe from our results that introducing closed fishing periods reduces environmental damage more significantly than strategies directed towards increasing the risk perception for net fishing.

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“…Other epidemiological and experimental studies have shown evidence of genetic and epigenetic modifications and chronic diseases, due to pesticide exposure (Mostafalou & Abdollahi, 2013). Even so, the effects of pesticides on health in the Latin American region are poorly documented (Zúñiga-Venegas et al, 2022).…”

mentioning

confidence: 99%

Prenatal exposure to pesticide mixture in Argentina: A pilot study in puerperal women from Santa Fe province

Colussi,

Martinez,

Bellenger

et al. 2024

Birth Defects Research

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IntroductionThe epidemiological investigation of congenital anomalies (CA) represents a challenge due to the multiplicity of associated risk factors, notably environmental ones. The monitoring of genotoxic effects in different populations is a useful tool in human biomonitoring and has great biological importance in estimating the exposure risks to complex mixtures of chemical substances.ObjectiveThis study aimed to determine the presence of environmental xenobiotics and evaluate their genotoxic effect, in mothers of newborns with and without CA, and the possible association/correlation between those biomarkers and CA.Materials and methodsA descriptive case and control cross‐sectional study was developed on 290 postpartum women from Santa Fe, Argentina.ResultsSignificant differences were observed between both groups, for places of residence and gynecological variables. Metabolites of organochlorine (OC), organophosphate (OP), and pyrethroid (PYR) pesticides were detected. The most frequently detected compounds were atrazine (ATZ) (57.14%), carbendazim (CBZ) (46.42%), and methylparaben (46.42%), among others. A positive correlation was found between the number of pesticides in blood and genotoxic variables. On the other hand, mothers of children with genitourinary anomalies were the ones with the highest concentrations of ATZ and OP.Discussion and conclusionThese results showed a deep background in the health reality of Santa Fe, which could greatly impact the health of future adults, who have been born preterm. On the other hand, the mixture of pesticides detected confirms the environmental living conditions of women and the transplacental exposure to these compounds in each pregnancy. The potential effects on long‐term descendent health are unknown and unpredictable.

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Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review

Cited by 45 publications

References 296 publications

Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study

Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study

Collateral Effects of Insecticide-Treated Nets on Human and Environmental Safety in an Epidemiological Model for Malaria with Human Risk Perception

Prenatal exposure to pesticide mixture in Argentina: A pilot study in puerperal women from Santa Fe province

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