Health Effects of Radon Exposure

Kang, Jin Kyu; Seo, Songwon; Jin, Young Woo

doi:10.3349/ymj.2019.60.7.597

Cited by 71 publications

(28 citation statements)

References 50 publications

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“…At present, the pathogenic factors of NSCLC are not completely clear, but there are many risk factors, including smoking and occupational diseases [22]. Cancer development is accompanied by many gene interactions, including circRNA regulation [23].…”

Section: Discussionmentioning

confidence: 99%

Circ_100565 promotes proliferation, migration and invasion in non-small cell lung cancer through upregulating HMGA2 via sponging miR-506-3p

Wei

Zhang

et al. 2020

Cancer Cell Int

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Background: Circular RNAs (circRNAs) play a vital role in the development of various cancers. Circ_100565 was found to be a highly expressed circRNA in non-small cell lung cancer (NSCLC) tissues screened by microarray profiles of circRNAs. However, the role of circ_100565 in NSCLC still remains unknown. Methods: Microarray analysis was used to screen for differentially expressed circRNAs in NSCLC tissues. The expression levels of circ_100565, microRNA-506-3p (miR-506-3p) and high mobility group AT-hook 2 (HMGA2) were measured by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation was detected by cell counting kit-8 (CCK-8) and colony formation assays. Transwell assay was used to determine the migration and invasion of cells. Besides, Western blot (WB) analysis was performed to assess the levels of proliferation and metastasis-related proteins and HMGA2 protein. Moreover, animal experiments were used to confirm the effect of circ_100565 on NSCLC tumor growth in vivo. In addition, the interaction between miR-506-3p and circ_100565 or HMGA2 was confirmed by dualluciferase reporter, RNA immunoprecipitation (RIP) assay or biotin-labeled pull-down assay. Results: Circ_100565 was upregulated in NSCLC, and its high expression was positively associated with the poor overall survival of NSCLC patients. Silencing of circ_100565 suppressed the proliferation, migration and invasion of NSCLC cells in vitro and reduced the tumor growth of NSCLC in vivo. Circ_100565 could sponge miR-506-3p, and miR-506-3p could target HMGA2. Moreover, miR-506-3p inhibitor or HMGA2 overexpression could reverse the inhibition effect of circ_100565 knockdown on NSCLC progression. Conclusion: Circ_100565 increased HMGA2 expression to promote proliferation, migration and invasion in NSCLC via absorbing miR-506-3p. Our findings provided a new biomarker for NSCLC therapy.

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Section: Discussionmentioning

confidence: 99%

Circ_100565 promotes proliferation, migration and invasion in non-small cell lung cancer through upregulating HMGA2 via sponging miR-506-3p

Wei

Zhang

et al. 2020

Cancer Cell Int

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“…The authors reported that indoor radon levels increased the risk of stroke after adjusting for potential confounding factors (OR: 1.004 (95 CI: 1.001–1.007), p = 0.010), and they observed an association between indoor radon exposure over 100 Bq/m 3 and this disease (OR: 1.242 (95 CI: 1.069–1.444), p = 0.005) [ 30 ]. A prospective trial in the USA found a significant association between radon exposure and mortality from chronic obstructive pulmonary disease (COPD) [ 34 ]. However, the relationship of this exposure to diseases other than lung cancer, especially leukemia and COPD, remains controversial [ 35 , 36 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Survey of Radon Concentrations in the University of Granada in Southern Spain

Calvente

Núñez

Karimi

et al. 2021

IJERPH

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The objective of this pilot study was to gather and analyze data on radon concentrations in workplaces in three buildings of Granada University (Southern Spain) constructed in different centuries. All measurements were made at basement or ground floor level under normal use conditions except for one space (mineral store), in which measurements were compared between the door closed and open. Measurements were conducted during different time periods between October 2013 and March 2019 with a Radon-Scout PLUS portable Radonmonitor. The duration of continuous recordings at different sites ranged between 42 and 1104 h. Mean accumulated radon concentrations ranged between 12 and 95 Bq/m3, below the maximal level of 300 Bq/m3 set by the World Health Organization (WHO). Relatively high values were recorded in the oldest building (15th century), which was also poorly ventilated. Ventilation appeared to be an important factor in reducing radon levels, especially in areas less exposed to radon, such as Southern Spain.

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“…The higher the radon concentration in the air we breathe and the longer the exposure time, the greater is the risk of developing lung cancer. According to several studies [7][8][9], the risk increases linearly due to long-term permanent exposure to high radon concentrations within the buildings. In general, radon is the major contributor to the ionizing radiation dose to which the human being is naturally exposed, and it is, therefore, essential to adopt all measures that can mitigate the presence of this gas indoors [2].…”

Section: Radon Public Health Riskmentioning

confidence: 99%

Internet of Things (IoT) Technologies for Managing Indoor Radon Risk Exposure: Applications, Opportunities, and Future Challenges

2021

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Radon gas is a harmful pollutant with a well-documented adverse influence on public health. In poorly ventilated environments, that are often prone to significant radon levels, studies indicate a known relationship between human radon exposure and lung cancer. Recent technology advances, notably on the Internet of Things (IoT) ecosystem, allow the integration of sensors, computing, and communication capabilities into low-cost and small-scale devices that can be used for implementing specific cyber-physical systems (CPS) for online and real-time radon management. These technologies are crucial for improving the overall building indoor air quality (IAQ), contributing toward the so-called cognitive buildings, where human-based control is tending to decline, and building management systems (BMS) are focused on balancing critical factors, such as energy efficiency, human radon exposure management, and user experience, to achieve a more transparent and harmonious integration between technology and the built environment. This work surveys recent IoT technologies for indoor radon exposure management (monitoring, assessment and mitigation), and discusses its main challenges and opportunities, by focusing on methods, techniques, and technologies to answer the following questions: (i) What technologies have been recently in use for radon exposure management; (ii) how they operate; (iii) what type of radon detection mechanisms do they use; and (iv) what type of system architectures, components, and communication technologies have been used to assist the referred technologies. This contribution is relevant to pave the way for designing more intelligent and sustainable systems that rely on IoT and Information and Communications Technology (ICT), to achieve an optimal balance between these two critical factors: human radon exposure management and building energy efficiency.

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Health Effects of Radon Exposure

Cited by 71 publications

References 50 publications

Circ_100565 promotes proliferation, migration and invasion in non-small cell lung cancer through upregulating HMGA2 via sponging miR-506-3p

Circ_100565 promotes proliferation, migration and invasion in non-small cell lung cancer through upregulating HMGA2 via sponging miR-506-3p

Survey of Radon Concentrations in the University of Granada in Southern Spain

Internet of Things (IoT) Technologies for Managing Indoor Radon Risk Exposure: Applications, Opportunities, and Future Challenges

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