Health functions and related molecular mechanisms of ellagitannin-derived urolithins

Gandhi, Gopalsamy Rajiv; Antony, Poovathumkal James; Ceasar, Stanislaus Antony; Vasconcelos, Alan Bruno Silva; Montalvão, Monalisa Martins; Franca, Mariana Nobre Farias de; Resende, Aimara da Cunha; Sharanya, C. S.; Liu, Yi; Hariharan, Govindasamy; Gan, Ren‐You

doi:10.1080/10408398.2022.2106179

Cited by 14 publications

(3 citation statements)

References 152 publications

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“…Citrus fruits are reported to show various health-promoting effects, especially antioxidant activity. Numerous studies have confirmed that a diet rich in antioxidants is directly associated with the prevention of a variety of human diseases, such as neurological disorders, diabetes, cardiovascular diseases, obesity, and several cancers (4)(5)(6)(7)(8). Citrus juice is the main citrus product on the market, and it is proposed to be a vital dietary source of various nutrients and bioactive compounds, including dietary fibers (e.g., cellulose and pectin), sugars (e.g., glucose, fructose, and sucrose), ascorbic acid, minerals (e.g., calcium, phosphorus, and potassium), carotenoids, flavonoids, flavanone glycosides (e.g., neohesperidin, hesperidin, and naringin), phenolic compounds (e.g., hydroxybenzoic acid and hydroxycinnamic acid), and volatile compounds (e.g., terpenes and esters) (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Quality evaluation of citrus varieties based on phytochemical profiles and nutritional properties

Guo

Zheng

et al. 2023

Front. Nutr.

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IntroductionChina is one of the major producers and exporters of various kinds of citrus fruits. As one of China’s major citrus planting bases, Sichuan has a citrus planting area that exceeds 400,000 hectares. Meanwhile, citrus cultivation has become one of the important agricultural pillar industries in the region. Citrus fruits are reported to show various health-promoting effects, especially antioxidant activity. However, reports on the functional, nutritional and qualitative characteristics of different citrus varieties in Sichuan are still scarce.MethodsThe quality attributes (color parameters, shape, and size), juice properties (titratable acids and total soluble sugar), mineral elements, and health-promoting nutritional and functional components (protein, carbohydrates, fat, dietary fiber, ascorbic acid, phenolic acids, and flavonoids), as well as antioxidant properties of 10 typical citrus varieties cultivated in Sichuan, were systematically investigated and analyzed.Results and DiscussionSignificant differences among different citrus varieties were found. In particular, the total soluble sugar content of Mingrijian was higher than that of other citrus, suggesting its potential for fresh consumption and food processing. Moreover, a total of five flavonoids and nine phenolic acids were identified and quantified. Yuanhong, with higher contents of ascorbic acid and phenolic acids, was considered to be a valuable variety with excellent antioxidant capacity and can be used for value-added processing in the food industry. Principal component analysis and hierarchical cluster heatmap analysis suggested that there were significant differences among the 10 citrus varieties. Correlation analysis confirmed the significant contribution of ascorbic acid and phenolic acids to antioxidant capacity in citrus. The results can provide some references for the cultivation and selection of nutritious citrus fruits.

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Section: Introductionmentioning

confidence: 99%

Quality evaluation of citrus varieties based on phytochemical profiles and nutritional properties

Guo

Zheng

et al. 2023

Front. Nutr.

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“…Furthermore, E. lenta, G. pamelae and G. urolithifacens increasing in children GM after the interaction with the horses, are all involved in the bioconversion of dietary plant polyphenol to health-promoting and protective bioactive metabolites. For instance, Gordonibacter species are involved in the production of urolithin, whereas E. lenta is involved in enterolignans production (Bess et al, 2020;Yang et al, 2024), with both molecules possessing well known anti-in ammatory and anti-cancer properties (Gandhi et al, 2024). Similarly, D. invisus, also increasing after horse interaction, has been associated with the production of the anti-in ammatory cytokine adiponectin (Shi et al, 2022), a protecting agent from metabolic in ammation.…”

Section: Discussionmentioning

confidence: 99%

A 15-day biodiversity intervention with horses in a farm system leads to acquisition of health-promoting features in the gut microbiome of 10 urban Italian children

Candela,

Scicchitano,

Foresto

et al. 2024

Preprint

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In order to evaluate the possibility to shape the human gut microbiome (GM) through the interaction with natural ecosystems, we explored the impact of a 15-day biodiversity intervention with horses on the GM of 10 urban-living Italian children. The children GM was metagenomically assessed before and after 10hr/day daily interaction with horses in an educational farm. The horses’ skin, oral, and fecal microbiomes were similarly assessed as well. We found that the interaction with horses facilitates the acquisition of health promoting features in the children GM, such as a higher diversity, an enhanced production of butyrate and the increase of several health-promoting species, generally considered as next-generation probiotics. Amongst these, the butyrate producers Facecalibacterium prausnitzii and F. ducaniae and a species belonging to the anti-inflammatory Christensenellales. Moreover, the interaction with horses were also associating with the increase of GM components exerting important roles in the bioconversion of dietary plant polyphenols to health promoting and protective metabolites, as Eggerthella lenta, Gordonibacter pamelae and G. urolithifacens. Supporting the microbiological safety of the interaction process, we did not observe any increases pathogenic features in the children GM following the interaction with horses. Overall, our pilot study provides insights into the existence of possible health-promoting variations in the GM from urban-living children thanks to the interactions with horses. This lays the foundations to explore the full extent of the beneficial interaction process occurring between the human GM and the natural microbiomes.

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“…LDH inhibitors have exhibited protective effects against ischemia-reperfusion injury and heart failure in preclinical studies ( Zhou et al, 2015 ). For example, in a rat model simulating myocardial ischemia-reperfusion injury, the LDH inhibitor galloflavin showed the potential to decrease infarct size and improve cardiac function ( Gandhi et al, 2022 ). EGCG has also been shown to inhibit LDH activity, leading to reduced lactate production and cardioprotective effects ( Eng et al, 2018 ).…”

Section: Ldh Inhibitors: Types Mechanisms and Therapeutic Applicationsmentioning

confidence: 99%

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Han,

Lee,

Park

et al. 2023

Front. Pharmacol.

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Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases. Targeting LDH has emerged as a vital approach in drug discovery, leading to the identification of LDH inhibitors among natural compounds, such as polyphenols, alkaloids, and terpenoids. These compounds demonstrate therapeutic potential against LDH-related diseases, including anti-cancer effects. However, challenges concerning limited bioavailability, poor solubility, and potential toxicity must be addressed. Combining natural compounds with LDH inhibitors has led to promising outcomes in preclinical studies. This review highlights the promise of natural compounds as LDH inhibitors for treating cancer, cardiovascular, and neurodegenerative diseases.

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Health functions and related molecular mechanisms of ellagitannin-derived urolithins

Cited by 14 publications

References 152 publications

Quality evaluation of citrus varieties based on phytochemical profiles and nutritional properties

Quality evaluation of citrus varieties based on phytochemical profiles and nutritional properties

A 15-day biodiversity intervention with horses in a farm system leads to acquisition of health-promoting features in the gut microbiome of 10 urban Italian children

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

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