Health impact on the elderly survivors of COVID-19: Six months follow up

Carrillo-García, Pamela; Garmendia-Prieto, Blanca; Cristofori, G; Lozano-Montoya, Isabel; Gómez-Pavón, Javier

doi:10.1016/j.regg.2022.03.004

Cited by 8 publications

(10 citation statements)

References 6 publications

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“…The effect of COVID-19 hospitalization on the functional decline and quality of life of surviving patients was already evidenced by some researchers [ 29 , 30 , 31 , 32 , 33 ]. However, all these studies were based on a shorter follow-up or younger cohorts, limiting the comparability of the obtained data on patients ≥80 years.…”

Section: Discussionmentioning

confidence: 94%

Long-Term Effects of Hospitalization for COVID-19 on Frailty and Quality of Life in Older Adults ≥80 Years

Covino

Russo

Salini

et al. 2022

JCM

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Objectives: This study aimed to assess the effects of frailty and the perceived quality of life (QOL) on the long-term survival (at least 1 year) of patients ≥ 80 years hospitalized for COVID-19 and the predictors of frailty and QOL deterioration in survivors. Design: This is a single-center, prospective observational cohort study. Setting and Participants: The study was conducted in a teaching hospital and enrolled all COVID-19 patients ≥80 years old consecutively hospitalized between April 2020 and March 2021. Methods: Clinical variables assessed in the Emergency Department (ED), and during hospitalization, were evaluated for association with all-cause death at a follow-up. Frailty was assessed by the clinical frailty scale (CFS), and the QOL was assessed by the five-level EuroQol EQ-5d tool. Multivariate Cox regression analyses and logistic regression analyses were used to identify independent factors for poor outcomes. Results: A total of 368 patients aged ≥80 years survived the index hospitalization (age 85 years [interquartile range 82–89]; males 163 (44.3%)). Compared to non-frail patients (CFS 1–3), patients with CFS 4–6 and patients with CFS 7–9 had an increased risk of death (hazard ratio 6.75 [1.51, 30.2] and HR 3.55 [2.20, 5.78], respectively). In patients alive at the 1-year follow-up, the baseline QOL was an independent predictor of an increase in frailty (OR 1.12 [1.01, 1.24]). Male sex was associated with lower odds of QOL worsening (OR 0.61 [0.35, 1.07]). Conclusions and Implications: In older adults ≥80 years hospitalized for COVID-19, the frailty assessment by the CFS could effectively stratify the risk of long-term death after discharge. In survivors, the hospitalization could produce a long-term worsening in frailty, particularly in patients with a pre-existing reduced baseline QOL. A long-term reduction in the perceived QOL is frequent in ≥80 survivors, and the effect appears more pronounced in female patients.

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Section: Discussionmentioning

confidence: 94%

Long-Term Effects of Hospitalization for COVID-19 on Frailty and Quality of Life in Older Adults ≥80 Years

Covino

Russo

Salini

et al. 2022

JCM

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“…23 60 Regarding age, five studies in this review included older adults. 28 37 44 47 58 Studies with samples of older adults suggested there is a high percentage of cognitive impairment in this group - 60% three months after the infection 47 and 30% after six months. 37 The incidence of cognitive impairment 12 months after discharge was 12.45%.…”

Section: Discussionmentioning

confidence: 95%

“…28 37 44 47 58 Studies with samples of older adults suggested there is a high percentage of cognitive impairment in this group - 60% three months after the infection 47 and 30% after six months. 37 The incidence of cognitive impairment 12 months after discharge was 12.45%. 58 These findings suggest that cognitive changes in post-acute COVID-19 are of particular concern among older patients, even more so, if they were severely infected.…”

Section: Discussionmentioning

confidence: 95%

“…Of the 47 studies included, four were published in 2020, 17 in 2021, and 26 in 2022. Of the total, 17 studies had a cross-sectional design, 7 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 19 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 had a longitudinal design, nine prospective longitudinal designs, 53 54 55 56 57 58 59 60 61 one prospective case-control 62 and one prospective controlled cohort design 63 ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Three studies included individuals aged ≥ 40 years. 21 43 64 Individuals aged ≥ 60 years comprised the samples investigated in five studies, 28 37 44 47 58 whereas two studies established no age constraints. 19 27 Regarding the age profile of the reviewed studies, the lowest mean age was 28.6 years 23 and the highest was 88.5 years.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Cognitive impairment in post-acute COVID-19 syndrome: a scoping review

Cipolli,

Alonso,

Yasuda

et al. 2023

Arq Neuropsiquiatr

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Emerging studies indicate the persistence of symptoms beyond the acute phase of COVID-19. Cognitive impairment has been observed in certain individuals for months following infection. Currently, there is limited knowledge about the specific cognitive domains that undergo alterations during the post-acute COVID-19 syndrome and the potential impact of disease severity on cognition. The aim of this review is to examine studies that have reported cognitive impairment in post-acute COVID-19, categorizing them into subacute and chronic phases. The methodology proposed by JBI was followed in this study. The included studies were published between December 2019 and December 2022. The search was conducted in PubMed, PubMed PMC, BVS – BIREME, Embase, SCOPUS, Cochrane, Web of Science, Proquest, PsycInfo, and EBSCOHost. Data extraction included specific details about the population, concepts, context, and key findings or recommendations relevant to the review objectives. A total of 7,540 records were identified and examined, and 47 articles were included. The cognitive domains most frequently reported as altered 4 to 12 weeks after acute COVID-19 were language, episodic memory, and executive function, and after 12 weeks, the domains most affected were attention, episodic memory, and executive function. The results of this scoping review highlight that adults with post-acute COVID-19 syndrome may have impairment in specific cognitive domains.

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COVID in Older People: Some Answers, New Questions

Rodríguez-Sánchez

Mañas

2023

The Journal of nutrition, health and aging

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Health impact on the elderly survivors of COVID-19: Six months follow up

Cited by 8 publications

References 6 publications

Long-Term Effects of Hospitalization for COVID-19 on Frailty and Quality of Life in Older Adults ≥80 Years

Long-Term Effects of Hospitalization for COVID-19 on Frailty and Quality of Life in Older Adults ≥80 Years

Cognitive impairment in post-acute COVID-19 syndrome: a scoping review

COVID in Older People: Some Answers, New Questions

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