Health Insurance and Blood Pressure Control

Norris, Keith C.

doi:10.1161/jaha.116.005130

Cited by 5 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypertension is a pandemic disease worldwide, particularly affecting 65–75% of individuals older than 65 years. Disruptions in neurovascular coupling are considered to be related to hypertension, which can cause diseases including cognitive decline, stroke, and certain microvascular diseases ( Gianaros et al, 2009 ; Wright and Harding, 2010 ; Li et al, 2013a , 2014 , 2015 ; Queiroz et al, 2013 ; Fang et al, 2016 ; Norris, 2016 ; Men et al, 2017 ). Patients with hypertension exhibit poor performance in language, processing speed, visuospatial abilities, attention, executive functioning, and memory ( Harrison et al, 2012 ; Muela et al, 2017 ; Ticcinelli et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Alteration in Brain Functional and Effective Connectivity in Subjects With Hypertension

Huo

et al. 2018

Front. Physiol.

View full text Add to dashboard Cite

To reveal the physiological mechanism of the cognitive decline in subjects with hypertension, the functional connectivity (FC) was assessed by using the wavelet phase coherence (WPCO), and effective connectivity (EC) was assessed by using the coupling strength (CS) of near-infrared spectroscopy (NIRS) signals. NIRS signals were continuously recorded from the prefrontal cortex, sensorimotor cortex, and occipital lobes of 13 hypertensive patients (hypertension group, 70 ± 6.5 years old) and 16 elderly healthy subjects (control group, 71 ± 5.5 years old) in resting and standing periods. WPCO and CS were calculated in four frequency intervals: I, 0.6–2; II, 0.145–0.6; III, 0.052–0.145; and IV, 0.021–0.052 Hz. CS quantifies coupling amplitude. In comparison with the control group, the hypertension group showed significantly decreased (p < 0.05) WPCO and CS in intervals III and IV and in the resting and standing states. WPCO and CS were significantly decreased in the resting state compared with those in the standing state in the hypertension group (p < 0.05). Decreased WPCO and CS indicated a reduced network interaction, suggesting disturbed neurovascular coupling in subjects with hypertension. Compared with the control group, the hypertension group showed significantly lower Mini-Mental State Examination (MMSE) (p = 0.028) and Montreal Cognitive Assessment (MoCA) scores (p = 0.011). In the hypertension group, correlation analysis showed that WPCO and CS were significantly positively correlated with MMSE and MoCA scores, respectively. These findings may provide evidence of impaired cognitive function in hypertension and can enhance the understanding on neurovascular coupling.

show abstract