This article presents the results from a descriptive cross-sectional survey that was conducted to assess the health information literacy skills of women of childbearing age in rural Lake Zone, Tanzania. A total of 349 women were involved in the study. The study found that most rural women in the study area have low levels of health information literacy. The aggregate scores of health information literacy indicate a mean of 42.86% with a normal distribution curve, and estimated close-to-zero skewness (0.172) and kurtosis (−0.297) measures. The causal relationships between health information literacy and women’s socio-demographic factors indicate a positive and statistically significant effect ( p < .01) of women’s level of education, income, ownership of means of communication and access to health facilities on their level of health information literacy. The women’s inadequate ability to access, read, understand, appraise and use health information is a barrier to their acquisition of relevant health information. Enhancing the health information literacy skills of these women is most likely to improve their health outcomes.