Objective: To investigate the long-term effects of multidisciplinary allocation of pain treatment on pain intensity, functional disability, depression, and medication use in outpatients with chronic pain, and to identify cognitive-behavioral predictors [worrying, avoidance behavior, fear of pain, helplessness, and acceptance] of the primary outcome measures.Methods: Eighty-six outpatients with chronic pain who were treated at a multidisciplinary pain center completed various questionnaires and a pain diary one week before treatment started, and 3 and 12 months later.Results: Functional disability and depression improved significantly 12 months after the start of treatment in comparison with before treatment. The decrease in scores for the cognitivebehavioral variables worrying, fear of pain, helplessness, and avoidance behavior at three months was associated with the decrease in functional disability and depression at 12 months.Conclusion: Patients with chronic pain may benefit in the long term from multidisciplinary allocation to pain treatment with respect to functional disability and depression. Changes of cognitive-behavioral processes seem to contribute to achieving long-term effects of multidisciplinary allocation of pain treatment. There is a need for high quality clinical trials in this field in order to clarify the specific contribution of cognitive-behavioral process variables.