Health outcomes among infants born to women deployed to United States military operations during pregnancy

Ryan, Margaret A. K.; Jacobson, Isabel G.; Sevick, Carter; Smith, Tyler C.; Gumbs, Gia R; Conlin, Ava Marie S

doi:10.1002/bdra.20746

Cited by 13 publications

(7 citation statements)

References 60 publications

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“…Data on liveborn neonates resulting from these pregnancies were obtained by linking pregnancy episodes to V3x.xx-coded neonatal hospital discharge records as per current Department of Defense Birth and Infant Health Registry methodology. 17 For the present study, the exposed group included active-duty military women who received the pandemic H1N1 vaccine ( 30,2009. Pregnancies exposed to both pandemic H1N1 vaccine and 2008-2009 seasonal influenza vaccine were included in the pandemic H1N1-exposed group but not the comparison group.…”

Section: Population and Methodsmentioning

confidence: 99%

Safety of the Pandemic H1N1 Influenza Vaccine Among Pregnant U.S. Military Women and Their Newborns

Conlin

Bukowinski

Sevick

et al. 2013

Obstetrics &Amp; Gynecology

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Section: Population and Methodsmentioning

confidence: 99%

Safety of the Pandemic H1N1 Influenza Vaccine Among Pregnant U.S. Military Women and Their Newborns

Conlin

Bukowinski

Sevick

et al. 2013

Obstetrics &Amp; Gynecology

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“…Moreover, a recent study shows that preterm infants exhibit abnormalities in cortical volume, compared to antenatal matched controls (Lodygensky et al, 2010). Another study reports increased incidence of preterm birth and neurodevelopmental disorders in offspring of women deployed to a combat zone while pregnant (Ryan et al, 2011). …”

Section: Influence Of Stress On Spine and Dendrite Remodeling: Prementioning

confidence: 99%

Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression

2013

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Dendritic spines provide a compartment for assembly and functional organization of synaptic machinery that plays a fundamental role in neuronal communication and neuroplasticity. Studies in humans as well as in animal models have demonstrated abnormal spine architecture in several psychiatric disorders, including depression and other stress related illnesses. The negative impact of stress on the density and organization of spines is thought to contribute to the behavioral deficits caused by stress exposure. Moreover, there is now evidence that medication-induced recovery involves changes in synaptic plasticity and dendrite morphology, including increased expression of pre- and postsynaptic plasticity related proteins, as well as the density and function of axo-spinous synapses. Here we review the evidence from brain imaging and postmortem studies demonstrating that depression is accompanied by structural and functional alterations of cortical and limbic brain regions, including the prefrontal cortex, hippocampus and amygdala. In addition, we present more direct evidence from basic research studies that exposure to stress alters spine morphology, function and plasticity and that antidepressants, particularly new rapid acting agents, reverse these effects. Elucidation of the signaling pathways and molecular mechanisms that control spine synapse assembly and plasticity will contribute to a better understanding of the pathophysiology of depression and development of novel, more effective therapeutic agents.

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“…After hurricane Katrina, over a two-fold increase in the incidence of preterm births was reported among pregnant women who were residing in a severely hit area, compared to those in less damaged areas (Xiong et al, 2008). Similarly, offspring born to women enlisted in the military that were deployed to a combat zone while pregnant, have a greater incidence of preterm birth and neurodevelopmental disorders, such as a major birth defect or malignancy (Ryan et al, 2011). Thus, chronic and/or salient PNS may promote neurodevelopmental disorder among people.…”

Section: Neurodevelopmental Neuropsychiatric and Neurodegenerative mentioning

confidence: 99%

Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review

et al. 2011

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Maternal–offspring interactions begin prior to birth. Experiences of the mother during gestation play a powerful role in determining the developmental programming of the central nervous system. In particular, stress during gestation alters developmental programming of the offspring resulting in susceptibility to sex-typical and stress-sensitive neurodevelopmental, neuropsychiatric, and neurodegenerative disorders. However, neither these effects, nor the underlying mechanisms, are well understood. Our hypothesis is that allopregnanolone, during gestation, plays a particularly vital role in mitigating effects of stress on the developing fetus and may mediate, in part, alterations apparent throughout the lifespan. Specifically, altered balance between glucocorticoids and progestogens during critical periods of development (stemming from psychological, immunological, and/or endocrinological stressors during gestation) may permanently influence behavior, brain morphology, and/or neuroendocrine-sensitive processes. 5α-reduced progestogens are integral in the developmental programming of sex-typical, stress-sensitive, and/or disorder-relevant phenotypes. Prenatal stress (PNS) may alter these responses and dysregulate allopregnanolone and its normative effects on stress axis function. As an example of a neurodevelopmental, neuropsychiatric, and/or neurodegenerative process, this review focuses on responsiveness to drugs of abuse, which is sensitive to PNS and progestogen milieu. This review explores the notion that allopregnanolone may effect, or be influenced by, PNS, with consequences for neurodevelopmental-, neuropsychiatric-, and/or neurodegenerative- relevant processes, such as addiction.

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Health outcomes among infants born to women deployed to United States military operations during pregnancy

Cited by 13 publications

References 60 publications

Safety of the Pandemic H1N1 Influenza Vaccine Among Pregnant U.S. Military Women and Their Newborns

Safety of the Pandemic H1N1 Influenza Vaccine Among Pregnant U.S. Military Women and Their Newborns

Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression

Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review

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