Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature

Fauser, Bart C.J.M.; Devroey, Paul; Diedrich, K.; Balaban, Başak; Bonduelle, M; Waal, Henriëtte A. Delemarre-van de; Estella, Carlos; Ezcurra, D.; Geraedts, J. P. M.; Howles, Colin M.; Lerner‐Geva, Liat; Serna, J.; Wells, Dagan

doi:10.1016/j.rbmo.2013.10.013

Cited by 115 publications

(73 citation statements)

References 233 publications

(251 reference statements)

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“…Likewise, it is also plausible to associate poorer outcomes to the assisted reproduction procedures themselves in addition to the patients' characteristics. As it stands, however, the effect of assisted reproduction procedures on the health of children born using ART is not fully understood and our data is suggestive that infertility in itself is a risk factor for congenital anomalies given the equal rate of anomalies recorded in infertile patients conceiving spontaneously [27,38].…”

Section: Discussionmentioning

confidence: 72%

Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies

Levi-Setti

Moioli

Smeraldi

et al. 2016

J Assist Reprod Genet

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Purpose The aim of this study was to provide a comprehensive follow-up of fetal and perinatal outcome and the incidence of congenital anomalies in babies born after fresh embryo transfers compared to those conceived spontaneously in infertile couples. Methods Retrospective comparative analysis of all clinical pregnancies from fresh cleavage-stage embryo transfer cycles (IVF and ICSI) compared with infertile patients who conceived spontaneously in the same time period (control). Congenital anomalies were classified following the European Surveillance of Congenital Anomalies (EUROCAT) classification. Results A total of 2414 assisted reproductive technology (ART) pregnancies were compared to 582 spontaneous conceptions in the control infertile group representing 2306 deliveries. No significant differences were found in pregnancy outcome between the two groups (delivery rate, abortion rate, ectopic pregnancies, medical abortions for fetal anomalies, single and twins mean gestational age, and weight at delivery). A significant difference (p < 0.001) was found in the twin (21.3 vs 2.3 %) and triplet rates (2.3 vs 0 %). A total of 2351 babies were delivered in the ART group and 449 in the control group. A total of 90 babies (3.8 %) were diagnosed with a major congenital anomaly in the ART group and 15 (3.3 %) in the control group (p = ns). The overall rate of major congenital anomalies (105/2800) in ART and spontaneous pregnancies in infertile couples was significantly higher when compared to the EUROCAT 2.0 versus 3.75 % (p = 0.0002). Discussion Babies born after ART treatments and from spontaneous conception in infertile couples had rates of congenital anomalies higher than those recorded by the EUROCAT. However, the rates of anomalies were not different within the infertile population whether conceived by ART or spontaneously. These data suggest that the diagnosis of infertility in itself is the common denominator for the increase in the rates of anomalies seen in both ART and spontaneous conceptions.

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Section: Discussionmentioning

confidence: 72%

Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies

Levi-Setti

Moioli

Smeraldi

et al. 2016

J Assist Reprod Genet

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“…The most apparent being that ICSI is associated with increased costs. Furthermore, ICSI carries with it potential risks, both demonstrated and theoretical, although there are many limitations to this data [40][41][42]. These potential risks should be a deterrent to the universal utilization of ICSI until definitive studies are complete.…”

Section: Discussionmentioning

confidence: 99%

Sibling Oocytes Randomly Assigned to Either Conventional Fertilization or Intracytoplasmic Sperm Injection Demonstrate Equivalent Fertilization and Blastulation Rates

Tobler¹,

Brezina²

2014

J IVF Reprod Med Genet

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Background: To determine the difference in fertilization and blastulation rates between sibling oocytes randomly assigned to either Conventional Fertilization (CF) or Intracytoplasmic Sperm Injection (ICSI) in patient couples with normal semen analysis parameters. Methods:A retrospective review of embryologic and clinical outcomes from patients undergoing their first In Vitro Fertilization (IVF) cycle that randomly assigned one-half of sibling oocytes to either CF or ICSI. Randomization occurred prior to removal of the oocyte cumulus cells which allows identification of metaphase II oocytes eligible for ICSI. All male partners met normal semen analysis parameters and normal fertilization was anticipated for the IVF cycle. Each patient served as their own control.Results: A total of 682 oocytes were included and were assigned to either CF or ICSI. The CF had a significantly higher fertilization rate compared to ICSI (67.9% versus 60%) when immature (non-metaphase II) oocytes were included in the analysis; however this difference diminished when only those oocytes eligible for ICSI were included. There was no difference in the day-3 embryo progression, the blastulation rate, the mean number of oocytes fertilized and the mean number of blastocysts per IVF cycle. Additionally, there was no significant difference in the pregnancy related outcomes between the two groups.Conclusions: These studies demonstrates that in patient couples with normal semen analysis parameters, undergoing their first IVF cycle and who have anticipate normal fertilization, randomly assigning oocytes to CF or ICSI does not improve fertilization or blastulation. To confirm these findings, larger prospective studies are required.

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“…In vitro fertilization-conceived children have lower birthweights and higher peripheral fat, blood pressure, and fasting glucose concentrations than controls. Women undergoing assisted reproduction are often older, which increases the chances of obtaining abnormal gametes that may cause deviations in outcomes between assisted-conception and naturally conceived children (Fausera et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Reproductive outcome of a case with familial balanced translocation t(3;6): implications for genetic counseling

et al. 2015

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ABSTRACT.Although it is known that parental carriers of structural chromosomal rearrangements are associated with recurrent pregnancy loss, subsequent natural pregnancies remain possible. We examined the reproductive outcome of a familial balanced translocation with t(3;6) (q12;q27). Karyotyping of the proband revealed 46,XY chromosomes with the balanced translocation t(3;6). The first 2 pregnancies resulted in spontaneous abortions. Based on the proband karyotype, his father and half-brother were subjected to cytogenetic analysis, and both showed 46,XY, t(3;6)(q12;q27). After genetic counseling, the proband chose to continue the pregnancy. During the third pregnancy, the subject gave birth to a normal male infant. For parental carriers with balanced chromosomal translocations, natural pregnancy should be considered during genetic counseling.

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Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature

Cited by 115 publications

References 233 publications

Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies

Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies

Sibling Oocytes Randomly Assigned to Either Conventional Fertilization or Intracytoplasmic Sperm Injection Demonstrate Equivalent Fertilization and Blastulation Rates

Reproductive outcome of a case with familial balanced translocation t(3;6): implications for genetic counseling

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