Health-Promoting Activities and Associated Mechanisms of Polygonati Rhizoma Polysaccharides

Abstract

Polygonati Rhizoma, a typical homology of medicine and food, possesses remarkable anti-fatigue, anti-aging, metabolic regulatory, immunomodulatory, anti-inflammatory, neuroprotective, anti-diabetes, and anti-cancer effects. Among bioactive phytochemicals in Polygonati Rhizoma, polysaccharides play important roles in the health-promoting activities through the mechanisms mentioned above and potential synergistic effects with other bioactives. In this review, we briefly introduce the updated biosynthesis of polysaccharides, the purification method, the structure characterization, and food applications, and discuss in detail the biological activities of Polygonati Rhizoma polysaccharides and associated mechanisms, aiming at broadening the usage of Polygonati Rhizoma as functional food and medicine.

Interpreting the Mechanism of Active Ingredients in Polygonati Rhizoma in Treating Depression by Combining Systemic Pharmacology and In Vitro Experiments

“…Traditional Chinese Medicinal herbs of the genus Polygonatum have been used as a tonic in China, India, Pakistan, Iran, and Japan [ 56 ]. The crude extract and some pure compounds of PR have many pharmacological effects, such as anti-aging, anti-diabetes, anti-fatigue, and anti-cancer [ 57 ]. The neuroprotective effects of PR have also received attention.…”

Pre-column Derivative HPLC and LC-Orbitrap-MS Analysis of Monosaccharides and Non-Polysaccharides in Polygonati Rhizoma

“…et Hemsl., Polygonatum sibiricum Red., and Polygonatum cyrtonema Hua. As a traditional Chinese medicinal herb, it is renowned for its high level of polysaccharides, which possess a myriad of medicinal values, including immune-modulating, anti-fatigue, antioxidant, and anti-tumor properties [1][2][3]. Considerable advancements have been achieved in the study concerning the polysaccharides derived from Polygonatum [4,5].…”

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

“…L. japonica polysaccharides are a kind of plant polysaccharide, which is mostly extracted by water, enzyme and ultrasonic coenzyme methods. The polysaccharide extracted by these methods has the following advantages: (1) the extracted polysaccharide content is high, (2) there are no of organic solvent residues, and (3) it is safer and more reliable in the development of food, drugs and cosmetics [23,24]. The safety and efficacy of L. japonica polysaccharides have enabled their use as additives in flower teas, healthy beverages, and throat lozenges.…”