Health Promoting Activities of Nigella sativa Seeds

Aydin, Ebru; Kart, Arzu

doi:10.1007/978-3-030-48798-0_11

Cited by 3 publications

(1 citation statement)

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“…NS essential oil has been markedly better at radical scavenging than many commercially available synthetic antioxidants ( 250 ). Recent work has shown that TQ, carvacrol, t-anethole, 4-terpineol, tannins, flavonoids, and alkaloids contribute to the radical scavenging properties of NSS with TQ and nigellone accounting for the majority of the activity ( 251 ). NS sustains the cellular microenvironment by increasing the body’s antioxidant enzymes, SOD, GPx, and CAT, and enhancing ROS scavenging capacity ( 169 ) by increasing vitamin C and E levels ( 252 ).…”

Section: The Role Of Herbal Medicine Formulations In Dm Treatmentmentioning

confidence: 99%

Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review

Shaukat,

Zaidi,

Anwar

et al. 2023

Front. Nutr.

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IntroductionLong used in traditional medicine, Nigella sativa (NS; Ranunculaceae) has shown significant efficacy as an adjuvant therapy for diabetes mellitus (DM) management by improving glucose tolerance, decreasing hepatic gluconeogenesis, normalizing blood sugar and lipid imbalance, and stimulating insulin secretion from pancreatic cells. In this review, the pharmacological and pharmacokinetic properties of NS as a herbal diabetes medication are examined in depth, demonstrating how it counteracts oxidative stress and the onset and progression of DM.MethodsThis literature review drew on databases such as Google Scholar and PubMed and various gray literature sources using search terms like the etiology of diabetes, conventional versus herbal therapy, subclinical pharmacology, pharmacokinetics, physiology, behavior, and clinical outcomes.ResultsThe efficiency and safety of NS in diabetes, notably its thymoquinone (TQ) rich volatile oil, have drawn great attention from researchers in recent years; the specific therapeutic dose has eluded determination so far. TQ has anti-diabetic, anti-inflammatory, antioxidant, and immunomodulatory properties but has not proved druggable. DM’s intimate link with oxidative stress, makes NS therapy relevant since it is a potent antioxidant that energizes the cell’s endogenous arsenal of antioxidant enzymes. NS attenuates insulin resistance, enhances insulin signaling, suppresses cyclooxygenase-2, upregulates insulin-like growth factor-1, and prevents endothelial dysfunction in DM.ConclusionThe interaction of NS with mainstream drugs, gut microbiota, and probiotics opens new possibilities for innovative therapies. Despite its strong potential to treat DM, NS and TQ must be examined in more inclusive clinical studies targeting underrepresented patient populations.

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