Health‐promoting effects of dietary polysaccharide extracted from <i>Dendrobium aphyllum</i> on mice colon, including microbiota and immune modulation

Liu, Huifan; Wu, Hui; Wang, Qin

doi:10.1111/ijfs.14050

Cited by 12 publications

(3 citation statements)

References 47 publications

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“…In the nutritional view of point, enrichment of sorghum biscuits with mushrooms enhanced the dietary fibre and β-glucan content. Previous study has illustrated a close association between an increase of dietary fibre consumption and a lower incidence of obesity and type-2 diabetes in relation to gut microbiota [67]. Daily consumption of 3 g of β-glucan is recommended to have a healthy indicate of cholesterollowering [68].…”

Section: Nutritional Valuementioning

confidence: 99%

Delivery of Phenolic Compounds, Peptides and β-Glucan to the Gastrointestinal Tract by Incorporating Dietary Fibre-Rich Mushrooms into Sorghum Biscuits

Brennan

et al. 2021

Foods

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Sorghum biscuits were enriched with mushroom powders (Lentinula edodes, Auricularia auricula and Tremella fuciformis) at 5%, 10% and 15% substitution levels. An in vitro gastrointestinal digestion was used to evaluate the effect of this enrichment on the phenolic content and soluble peptide content as well as antioxidant activities of the gastric or intestinal supernatants (bio-accessible fractions), and the remaining portions of phenolic compounds, antioxidants and β-glucan in the undigested residue (non-digestible fraction). The phenolic content of the gastric and intestinal supernatants obtained from digested mushroom-enriched biscuits was found to be higher than that of control biscuit, and the phenolic content was positively correlated to the antioxidant activities in each fraction (p < 0.001). L. edodes and T. fuciformis enrichment increased the soluble protein content (small peptide) of sorghum biscuits after in vitro digestion. All mushroom enrichment increased the total phenolic content and β-glucan content of the undigested residue and they were positively correlated (p < 0.001). The insoluble dietary fibre of biscuits was positively correlated with β-glucan content (p < 0.001) of undigested residue. These findings suggested that enriching food with mushroom derived dietary fibre increases the bioavailability of the non-digestible β-glucan and phenolic compounds.

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Section: Nutritional Valuementioning

confidence: 99%

Delivery of Phenolic Compounds, Peptides and β-Glucan to the Gastrointestinal Tract by Incorporating Dietary Fibre-Rich Mushrooms into Sorghum Biscuits

Brennan

et al. 2021

Foods

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“…Animal experiments in this study were conducted based on our previous work (Liu, Wu, & Wang, ). After randomly dividing the mice into two groups, at 9:00 am every day, one group was orally fed with 0.4 g/kg body weight DAP by gavage based on a previous report (J.‐L.…”

Section: Methodsmentioning

confidence: 99%

Possible Metabolic Pathway of a Novel Bioactive Polysaccharide Extracted from Dendrobium aphyllum: An In Vivo Study

Liu

Wang

2019

Journal of Food Science

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Our previous study characterized the structure-associated immunomodulatory effects of an edible Dendrobium aphyllum polysaccharide (DAP), and the in vitro gastrointestinal digestions highlighted DAP could be digested by the GI tract in some extent. Therefore, the present study further explored the digestive properties in vivo to infer the metabolic pathway with health mice model. Results revealed that DAP-treated group showed slightly lower blood glucose levels and significantly higher (P < 0.05) enzyme activities, namely G6Pase and GDH with an increment of about 0.4 to 0.9 and 45 to 91 U/mL, respectively. Meanwhile, DAP up-regulated the expression of glucose transporters, GLUT1 and GLUT2 in the increment rates of 56.34% to 68.28% and 76.63% to 83.03%, in colon. Furthermore, the beneficial effects of DAP on colon were confirmed by the increment of four types short chain fatty acids and the health-promoting microbiota diversity. The above results successfully identify the metabolic pathways after the oral administration of bioactive DAP.Practical application: The metabolic pathways of Dendrobium aphyllum polysaccharide, after artificially stimulated oral administration, were characterized. The most of the unabsorbed portion of DAP were utilized by the colon microbiota, resulting in the significantly increasing production of four health-promoting SCFAs. The unabsorbed portion of DAP upregulated the diversity of various beneficial microbiota genus, and meanwhile downregulated kinds of harmful microbiota genus.

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“…Dendrobium huoshanense polysaccharides altered the gut microbiota and improved the immune response (Xie et al, 2019) (Liu et al, 2019).…”

Section: Polysaccharides From Plantsmentioning

confidence: 99%

Improvement of Inflammation, Diabetes, and Obesity by Forest Product-Derived Polysaccharides through the Human Intestinal Microbiota

MYEONG,

LEE,

KIM

et al. 2023

J. Korean Wood Sci. Technol.

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The intestinal microbiota plays a crucial role in determining human health, rendering it a major focus of scientific investigation. Rather than eliminating all microbes, promoting the proliferation of beneficial microorganisms within the gut has been recognized as a more effective approach to improving health. Unfavorable conditions potentially alter gut microbial populations, including a reduction in microbial diversity. However, intentionally enhancing the abundance of beneficial gut microbes can restore a state of optimal health. Polysaccharides are widely acknowledged for their potential to improve the gut microbiota. This review emphasizes the findings of recent studies examining the effects of forest product-derived polysaccharides on enhancing the gut microbiota and alleviating inflammation, diabetes symptoms, and obesity. The findings of several studies reviewed in this paper strongly suggest that forest products serve as an excellent dietary source for improving the gut microbiota and potentially offer valuable dietary interventions for chronic health problems, such as inflammation, diabetes, and obesity.

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Health‐promoting effects of dietary polysaccharide extracted from Dendrobium aphyllum on mice colon, including microbiota and immune modulation

Cited by 12 publications

References 47 publications

Delivery of Phenolic Compounds, Peptides and β-Glucan to the Gastrointestinal Tract by Incorporating Dietary Fibre-Rich Mushrooms into Sorghum Biscuits

Delivery of Phenolic Compounds, Peptides and β-Glucan to the Gastrointestinal Tract by Incorporating Dietary Fibre-Rich Mushrooms into Sorghum Biscuits

Possible Metabolic Pathway of a Novel Bioactive Polysaccharide Extracted from Dendrobium aphyllum: An In Vivo Study

Improvement of Inflammation, Diabetes, and Obesity by Forest Product-Derived Polysaccharides through the Human Intestinal Microbiota

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